AQUEOUS OPHTHALMIC SOLUTIONS OF PHENTOLAMINE AND MEDICAL USES THEREOF
The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.
1 . A method of pupil reduction comprising administering to a subject an effective amount of an aqueous ophthalmic solution, wherein said method comprises:
(a) storing said aqueous ophthalmic solution at temperature in the range of 2-8° C.; and
(b) administrating said aqueous ophthalmic solution to the eye of a patient in the form of an eye drop;
wherein said aqueous ophthalmic solution comprises:
a. about 0.1% (w/v) to about 4% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
d. water; and
e. optionally one or more of a poly(C 2-4 alkylene) glycol polymer, dextran, pharmaceutically acceptable carrier, pharmaceutically acceptable salt, cellulose agent, carbohydrate, alkali metal halide, alkaline earth metal halide, boric acid, cyclodextrin, dextrose, glycerin, urea, viscosity modifying agent, solubilizing agent, surfactant, demulcent polymer, wetting agent, or water-miscible solvent;
wherein said aqueous ophthalmic solution has a pH of about 4.0 to about 7.5.
2 . The method of claim 1 , wherein the at least one polyol compound is mannitol.
3 . The method of claim 2 , wherein the solution has a pH of 4.5 to 5.5.
4 . The method of claim 3 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
5 . The method of claim 1 , wherein the aqueous ophthalmic solution comprises:
a. about 0.5% (w/v) to about 2% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. about 2% (w/v) to about 5% (w/v) of at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
e. optionally one or more of an alkali metal halide or alkaline earth metal halide.
6 . The method of claim 5 , wherein the at least one polyol compound is mannitol.
7 . The method of claim 6 , wherein the solution has a pH of 4.5 to 5.5.
8 . The method of claim 7 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
9 . The method of claim 1 , wherein the aqueous ophthalmic solution consists of:
a. about 0.1% (w/v) to about 4% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
d. water; and
e. optionally one or more of a poly(C 2-4 alkylene) glycol polymer, dextran, pharmaceutically acceptable carrier, pharmaceutically acceptable salt, cellulose agent, carbohydrate, alkali metal halide, alkaline earth metal halide, boric acid, cyclodextrin, dextrose, glycerin, urea, viscosity modifying agent, solubilizing agent, surfactant, demulcent polymer, wetting agent, or water-miscible solvent.
10 . The method of claim 9 , wherein the at least one polyol compound is mannitol.
11 . The method of claim 10 , wherein the solution has a pH of 4.5 to 5.5.
12 . The method of claim 11 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
13 . The method of claim 1 , wherein the aqueous ophthalmic solution consists of:
a. about 0.5% (w/v) to about 2% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. about 2% (w/v) to about 5% (w/v) of at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
e. optionally one or more of an alkali metal halide or alkaline earth metal halide.
14 . The method of claim 13 , wherein the at least one polyol compound is mannitol.
15 . The method of claim 14 , wherein the solution has a pH of 4.5 to 5.5.
16 . The method of claim 15 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
17 . The method of claim 1 , wherein the aqueous ophthalmic solution consists essentially of:
a. about 0.1% (w/v) to about 4% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
d. water; and
e. optionally one or more of a poly(C 2-4 alkylene) glycol polymer, dextran, pharmaceutically acceptable carrier, pharmaceutically acceptable salt, cellulose agent, carbohydrate, alkali metal halide, alkaline earth metal halide, boric acid, cyclodextrin, dextrose, glycerin, urea, viscosity modifying agent, solubilizing agent, surfactant, demulcent polymer, wetting agent, or water-miscible solvent.
18 . The method of claim 17 , wherein the at least one polyol compound is mannitol.
19 . The method of claim 18 , wherein the solution has a pH of 4.5 to 5.5.
20 . The method of claim 19 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
21 . The method of claim 1 , wherein the aqueous ophthalmic solution consists essentially of:
a. about 0.5% (w/v) to about 2% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
b. about 2% (w/v) to about 5% (w/v) of at least one polyol compound selected from the group consisting of mannitol, glycerol, propylene glycol, ethylene glycol, sorbitol, and xylitol;
c. about 0.1 mM to about 10 mM of at least one buffer;
e. optionally one or more of an alkali metal halide or alkaline earth metal halide.
22 . The method of claim 21 , wherein the at least one polyol compound is mannitol.
23 . The method of claim 22 , wherein the solution has a pH of 4.5 to 5.5.
24 . The method of claim 23 , wherein the phentolamine or a pharmaceutically acceptable salt thereof is phentolamine mesylate.
25 . The method of claim 1 , wherein about 1% (w/v) of phentolamine mesylate is present in the solution; the buffer comprises sodium acetate; and about 4% (w/v) mannitol is present in the solution.
26 . The method of claim 9 , wherein about 1% (w/v) of phentolamine mesylate is present in the solution; the buffer comprises sodium acetate; and about 4% (w/v) mannitol is present in the solution.
27 . The method of claim 17 , wherein about 1% (w/v) of phentolamine mesylate is present in the solution; the buffer comprises sodium acetate; and about 4% (w/v) mannitol is present in the solution.
28 . The method of claim 25 , wherein: (a) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 12 weeks; (b) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 24 weeks; or (c) less than 7% of the phentolamine mesylate degrades upon storage at 40° C. for 12 weeks.
29 . The method of claim 26 , wherein: (a) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 12 weeks; (b) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 24 weeks; or (c) less than 7% of the phentolamine mesylate degrades upon storage at 40° C. for 12 weeks.
30 . The method of claim 27 , wherein: (a) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 12 weeks; (b) less than 2% of the phentolamine mesylate degrades upon storage at 25° C. for 24 weeks; or (c) less than 7% of the phentolamine mesylate degrades upon storage at 40° C. for 12 weeks.