COMBINATION DOSAGE FORMS AND ADMINISTRATION THEREOF
This disclosure relates to methods of administering bupropion, such as S-bupropion or R-bupropion, in conjunction with tetrabenazine, alpha-dihydrotetrabenazine, or beta-dihydrotetrabenazine to a human being. Dosage forms, drug delivery systems, and methods related to tetrabenazine, alpha-dihydrotetrabenazine, or beta-dihydrotetrabenazine and bupropion, such as S-bupropion or R-bupropion, are also disclosed.
1 - 24 . (canceled)
25 . A dosage form, comprising from about 5 mg to about 30 mg of a tetrabenazine or a pharmaceutically acceptable salt thereof and bupropion hydrochloride, wherein the dosage form is a solid or a liquid dosage form, and wherein the tetrabenazine is not deuterium-modified.
26 . The dosage form of claim 25 , wherein the dosage form is a solid dosage form.
27 . The dosage form of claim 25 , comprising from about 70 mg to about 140 mg of the bupropion hydrochloride.
28 . The dosage form of claim 25 , comprising from about 10 mg to about 15 mg of the tetrabenazine or a pharmaceutically acceptable salt thereof.
29 . The dosage form of claim 28 , comprising from about 90 mg to about 110 mg of the bupropion hydrochloride.
30 . The dosage form of claim 25 , comprising from about 90 mg to about 110 mg of the bupropion hydrochloride.
31 . The dosage form of claim 25 , wherein the bupropion hydrochloride comprises (S)-bupropion hydrochloride.
32 . The dosage form of claim 31 , wherein the (S)-bupropion hydrochloride has an enantiomeric excess of at least 97%.
33 . The dosage form of claim 25 , comprising from about 70 mg to about 100 mg of the bupropion hydrochloride.
34 . The dosage form of claim 25 , comprising from about 100 mg to about 140 mg of the bupropion hydrochloride.
35 . The dosage form of claim 25 , comprising from about 9 mg to about 12 mg of the tetrabenazine or a pharmaceutically acceptable salt thereof.
36 . The dosage form of claim 25 , comprising from about 12 mg to about 15 mg of the tetrabenazine or a pharmaceutically acceptable salt thereof.
37 . The dosage form of claim 25 , wherein the bupropion hydrochloride is not deuterium-modified.
38 . The dosage form of claim 25 , wherein the bupropion hydrochloride comprises from about 70 mg to about 140 mg of (S)-bupropion hydrochloride.
39 . The dosage form of claim 38 , wherein the (S)-bupropion hydrochloride is not deuterium-modified.