ANTIMICROBIAL COMPOSITIONS, INCLUDING ANTIMICROBIAL HYDROGELS, EFFECTIVE AGAINST MATURE BIOFILMS
A method for the prevention or elimination of biofilm microorganisms on at least one surface of a medical device, the method comprising the steps of: (a) providing a biofilm-active composition having at least one biofilm-active agent; and (b) delivering the biofilm-active composition to the medical device in an amount sufficient to prevent or eliminate the biofilm microorganisms on at least one surface of the medical device.
1 . A method for the prevention or elimination of biofilm microorganisms on at least one surface of a medical device, the method comprising the steps of:
(a) providing a biofilm-active composition having at least one biofilm-active agent; and
(b) delivering the biofilm-active composition to the medical device in an amount sufficient to prevent or eliminate the biofilm microorganisms on at least one surface of the medical device.
2 . A method according to claim 1 wherein the biofilm-active composition is formed by mixing taurolidine or its derivatives thereof and a base material.
3 . A method according to claim 1 wherein the biofilm-active composition is contacted to the medical device for a period of time sufficient to act on at least one surface of the medical device.
4 . A method according to claim 1 wherein the biofilm-active composition is contacted to the medical device by integrating the biofilm-active composition within the medical device.
5 . A method according to claim 1 wherein the biofilm-active composition is contacted to the medical device for a period of time sufficient to substantially prevent the growth or eliminate biofilm microorganisms on the at least one surface of the medical device.
6 . A method according to claim 2 wherein the base material is a hydrogel.
7 . A method according to claim 6 wherein the hydrogel is hyaluronic acid.
8 . A method according to claim 1 wherein the biofilm-active composition further comprises a biofilm-penetrating agent.
9 . A method according to claim 8 wherein the biofilm-penetrating agent comprises at least one from the group consisting of long-chain or short-chain fatty acids or fatty alcohols.
10 . A method according to claim 9 wherein the biofilm-penetrating agent comprises at least one from the group consisting of myristic acid and myristyl alcohol.
11 . A biofilm-active and biofilm-penetrating composition having at least one biofilm-active agent and at least one biofilm-penetrating agent, wherein the biofilm-active and biofilm-penetrating composition is formed by mixing taurolidine or its derivatives thereof, a biofilm-penetrating agent, and a base material.
12 . A biofilm-active and biofilm-penetrating composition according to claim 11 wherein the biofilm-penetrating agent comprises at least one from the group consisting of long-chain or short-chain fatty acids or fatty alcohols.
13 . A biofilm-active and biofilm-penetrating composition according to claim 12 wherein the biofilm-penetrating agent comprises at least one from the group consisting of myristic acid and myristyl alcohol.
14 . A biofilm-active and biofilm-penetrating composition according to claim 11 wherein the base material is a hydrogel.
15 . A biofilm-active and biofilm-penetrating composition according to claim 14 wherein the hydrogel is hyaluronic acid.
16 . A system comprising:
a medical device; and
a biofilm-active and biofilm-penetrating composition applied to the medical device, wherein the biofilm-active and biofilm-penetrating composition comprises at least one biofilm-active agent.
17 . A system according to claim 16 wherein the biofilm-active and biofilm-penetrating composition is formed by mixing taurolidine or its derivatives thereof and a base material.
18 . A system according to claim 17 wherein the base material is a hydrogel.
19 . A system according to claim 18 wherein the hydrogel is hyaluronic acid.
20 . A system according to claim 16 wherein the biofilm-active and biofilm-penetrating composition further comprises a biofilm-penetrating agent.
21 . A system according to claim 20 wherein the biofilm-penetrating agent comprises at least one from the group consisting of long-chain or short-chain fatty acids or fatty alcohols.
22 . A system according to claim 21 wherein the biofilm-penetrating agent comprises at least one from the group consisting of myristic acid and myristyl alcohol.