METHODS, APPARATUSES, AND SYSTEMS FOR THE TREATMENT OF PULMONARY DISORDERS
Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.
1 . A method of treating a target tissue of a patient, comprising:
positioning at least one energy delivery body near the target tissue;
positioning a dispersive electrode upon the patient at a location that causes the at least one energy delivery body to function in a monopolar fashion; and
delivering pulsed high voltage energy through the energy delivery body, wherein the pulsed high voltage energy causes disruption of at least intracellular organelles of the target tissue leading to cell death by at least one non-thermal mechanism, wherein the pulsed high voltage energy has a voltage of 500 to 5000 volts and packets of pulses.
2 . The method of claim 1 , wherein the non-thermal mechanism comprises programmed cell death.
3 . The method of claim 1 , wherein the cell death causes an inflammatory cascade to ensue.
4 . The method of claim 1 , wherein the target tissue resides within a lung of the patient.
5 . The method of claim 1 , wherein positioning the at least one energy delivery body comprises advancing the at least one energy delivery body into a body passageway.
6 . The method of claim 5 , wherein the body passageway comprises a lung passageway.
7 . The method of claim 5 , wherein the body passageway comprises a blood vessel, a lymphatic vessel, a kidney tubule, an esophagus, a stomach, a small intestine, a large intestine, an appendix, a rectum, a bladder, a ureter, a pharynx, a mouth, a vagina, a urethra, or a duct of a gland.
8 . The method of claim 1 , wherein the at least one energy delivery body comprises one or more prongs.
9 . The method of claim 8 , wherein the one or more prongs comprise an insulating substrate.
10 . The method of claim 8 , further comprising withdrawing a sheath proximally so as to expose the one or more prongs.
11 . The method of claim 1 , wherein the at least one energy delivery body comprises a plurality of tines.
12 . The method of claim 1 , further comprising expanding the at least one energy delivery body.
13 . The method of claim 12 , wherein the at least one energy delivery body comprises a plurality of wires forming a basket.
14 . The method of claim 1 , further comprising repositioning the at least one energy delivery body after delivering the pulsed high voltage energy and thereafter delivering another dose of the pulsed high voltage energy, wherein the pulsed high voltage energy and the another dose of the pulsed high voltage energy are delivered to overlapping areas of the target tissue.
15 . The method of claim 1 , wherein the pulsed high voltage energy causes disruption of both cell membranes and the intracellular organelles of the target tissue, and wherein the pulsed high voltage energy has only a partial effect on the cell membranes or the intracellular organelles, and wherein a cumulative effect on the cell membranes or the intracellular organelles ultimately yields the cell death.
16 . A method for treating a target tissue of a patient, comprising:
positioning at least one energy delivery body near the target tissue;
positioning a dispersive electrode upon the patient at a location that causes the at least one energy delivery body to function in a monopolar fashion; and
delivering pulsed high voltage energy through the energy delivery body, wherein the pulsed high voltage energy comprises packets of pulses that cause disruption of both cell membranes and intracellular organelles of the target tissue, thereby leading to cell death by at least one non-thermal mechanism.
17 . The method of claim 16 , wherein the pulsed high voltage energy has only a partial effect on the cell membranes or the intracellular organelles, and wherein a cumulative effect on the cell membranes or the intracellular organelles ultimately yields the cell death.
18 . The method of claim 16 , wherein the non-thermal mechanism comprises programmed cell death.
19 . The method of claim 16 , wherein the cell death causes an inflammatory cascade to ensue.
20 . The method of claim 16 , wherein the target tissue resides within a lung of the patient.
21 . The method of claim 16 , wherein positioning the at least one energy delivery body comprises advancing the at least one energy delivery body into a body passageway.
22 . The method of claim 21 , wherein the body passageway comprises a lung passageway.
23 . The method of claim 21 , wherein the body passageway comprises a blood vessel, a lymphatic vessel, a kidney tubule, an esophagus, a stomach, a small intestine, a large intestine, an appendix, a rectum, a bladder, a ureter, a pharynx, a mouth, a vagina, a urethra, or a duct of a gland.
24 . The method of claim 16 , wherein the at least one energy delivery body comprises one or more prongs.
25 . The method of claim 24 , wherein the one or more prongs comprise an insulating substrate.
26 . The method of claim 24 , further comprising withdrawing a sheath proximally so as to expose the one or more prongs.
27 . The method of claim 16 , wherein the at least one energy delivery body comprises a plurality of tines.
28 . The method of claim 16 , further comprising expanding the at least one energy delivery body.
29 . The method of claim 28 , wherein the at least one energy delivery body comprises a plurality of wires forming a basket.
30 . The method of claim 16 , further comprising repositioning the at least one energy delivery body after delivering the pulsed high voltage energy and thereafter delivering another dose of the pulsed high voltage energy, wherein the pulsed high voltage energy and the another dose of the pulsed high voltage energy are delivered to overlapping areas of the target tissue.