METHOD FOR TREATING OSTEOARTHRITIS WITH MESENCHYMAL STEM CELL EXOSOMES
Disclosed herein are methods for treating osteoarthritis may be a one-step arthroscopic procedure and may include detaching synovial mesenchymal stem cells (MSCs) from the synovium using a brush device: covering articular cartilage in an affected joint with a scaffold, and placing concentrated MSC exosomes into the affected joint to stimulate differentiation of synovial MSCs into articular cartilage cells.
1 .- 6 . (canceled)
7 . A method of preventing a disease, disorder, injury or symptoms thereof affecting one or more joints in a subject comprising administering to a subject a therapeutically effective amount of a mesenchymal stem cell (MSC) exosome preparation.
8 . The method of claim 7 , wherein disease or disorder comprises juvenile arthritis, psoriatic arthritis, infectious arthritis, rheumatoid arthritis, ankylosing spondylitis, gout, bursitis, tendinosis, and/or tendonitis.
9 . The method of claim 7 , wherein the joint comprises the ankle, knee, hip, wrist, elbow, shoulder, knuckle, and/or neck.
10 . The method of claim 7 , wherein the MSC exosome preparation is administered to each joint affected by the disorder, disease, or injury.
11 . The method of claim 7 , wherein the MSC exosome preparation further comprises growth factors obtained from MSC.
12 . The method of claim 7 , wherein the MSC exosomes are administered via injection, MSC exosome carrying scaffold, hydrogel, and/or topical cream or salve.
13 . A method of treating, inhibiting, reducing, and/or ameliorating a disease, disorder, injury or symptoms thereof affecting one or more joints in a subject comprising administering to a subject a therapeutically effective amount of a mesenchymal stem cell (MSC) exosome preparation, wherein the symptoms comprise a tear in a piece of tissue.
14 . The method of claim 13 , wherein disease or disorder comprises sprain, labral tear, tear of a tendon, and/or tear of a ligament.
15 . The method of claim 13 , wherein the joint comprises the ankle, knee, hip, wrist, elbow, shoulder, knuckle, and/or neck.
16 . The method of claim 13 , wherein the MSC exosome preparation is administered to each joint affected by the disorder, disease, or injury.
17 . The method of claim 13 , wherein the MSC exosome preparation further comprises growth factors obtained from MSC.
18 . The method of claim 13 , wherein the MSC exosomes are administered via injection, MSC exosome carrying scaffold, hydrogel, and/or topical cream or salve.
19 . A method of preventing a disease, disorder, injury or symptoms thereof affecting one or more joints in a subject comprising administering to a subject a therapeutically effective amount of a mesenchymal stem cell (MSC) exosome preparation, wherein the symptoms comprise a tear in a piece of tissue.
20 . The method of claim 19 , wherein disease or disorder comprises sprain, labral tear, tear of a tendon, and/or tear of a ligament.
21 . The method of claim 19 , wherein the joint comprises the ankle, knee, hip, wrist, elbow, shoulder, knuckle, and/or neck.
22 . The method of claim 19 , wherein the MSC exosome preparation is administered to each joint affected by the disorder, disease, or injury.
23 . The method of claim 19 , wherein the MSC exosome preparation further comprises growth factors obtained from MSC.
24 . The method of claim 19 , wherein the MSC exosomes are administered via injection, MSC exosome carrying scaffold, hydrogel, and/or topical cream or salve.