NITRIC OXIDE GENERATION, DILUTION, AND TOPICAL APPLICATIONS, RAPID, PRECISE, NITRIC OXIDE ANALYSIS AND TITRATION APPARATUS, COMPOSITIONS, SYSTEMS, AND METHODS
Topical applications that provide a nitric oxide therapy to a surface are provided. Systems for providing a topical nitric oxide therapy can comprise a nitrite medium in a first container, the nitrite medium comprising about 3% of a nitrite component by weight. The system comprises an acidic medium in a second container, the acidic medium comprising about 9% by weight of one or more acidic reactants. The nitrite medium and the acidic medium are configured to be combined to form a nitric oxide topical medium producing nitric oxide suitable for topical application and suitable for administering nitric oxide therapy wherein a therapeutically effective amount of the nitric oxide topical medium is applied to a treatment surface suitable for receiving nitric oxide therapy, whereby the application of the therapeutically effective amount is adapted to deliver a dose of nitric oxide at the treatment surface of a patient.
1 - 9 . (canceled)
10 . A system for providing a topical nitric oxide therapy, comprising:
a nitrite medium in a first container, the nitrite medium comprising about 3% of a nitrite component by weight, wherein the nitrite component is sodium nitrite or potassium nitrite wherein the nitrite medium comprises greater than about 1% hydroxypropyl methylcellulose polymers by weight;
an acidic medium in a second container, the acidic medium comprising about 9% by weight of one or more acidic reactants, wherein the acidic reactant is selected from the group consisting of citric acid, lactic acid, ascorbic acid, acetic acid, and a combination thereof; and
wherein the nitrite medium and the acidic medium are configured to be combined to form a nitric oxide topical medium producing nitric oxide suitable for topical application and suitable for administering nitric oxide therapy wherein a therapeutically effective amount of the nitric oxide topical medium is applied to a treatment surface suitable for receiving nitric oxide therapy, whereby the application of the therapeutically effective amount is adapted to deliver a dose of nitric oxide at the treatment surface of a patient, wherein the treatment surface of a patient is the patient's skin.
11 . (canceled)
12 . The system of claim 10 , wherein one or more of the first and second containers are configured to dispense a medium by one or more of a pump action, a squeezing action, and a shaking action.
13 . The system of claim 10 , wherein the therapeutically effective amount of the topical medium is configured to produce nitric oxide gas having a concentration of between about 500 ppm and about 1000 ppm.
14 . The system of claim 10 , wherein the therapeutically effective amount of the topical medium is configured to produce nitric oxide gas having a concentration of between about 1000 ppm and about 2000 ppm.
15 . The system of claim 10 , wherein the dose of nitric oxide provides a localized vasodilation treatment to the patient.
16 . The system of claim 10 , wherein the dose of nitric oxide provides a systemic vasodilation treatment to the patient.
17 . A composition system comprising a combination of a nitrite medium and an acidic medium for production of a topical medium for topical application of nitric oxide therapy, the composition system comprising:
a nitrite medium in a first container, the nitrite medium comprising a nitrite component, wherein the nitrite component is sodium nitrite or potassium nitrite, wherein the nitrite medium comprises greater than about 1% hydroxypropyl methylcellulose polymers by weight;
an acidic medium in a second container, the acidic medium comprising an acidic component, wherein the acidic component is selected from the group consisting of citric acid, lactic acid, ascorbic acid, acetic acid, and a combination thereof; and
wherein the nitrite medium and the acidic medium are configured to be combined to form a nitric oxide topical medium producing nitric oxide suitable for topical application and suitable for administering nitric oxide therapy wherein a therapeutically effective amount of the nitric oxide topical medium is applied to a treatment surface suitable for receiving nitric oxide therapy, whereby the application of the therapeutically effective amount is adapted to deliver a dose of nitric oxide at the treatment surface of a patient, wherein the treatment surface of a patient is the patient's skin, wherein the treatment surface of a patient is the patient's skin.
18 . The composition system of claim 17 , wherein the nitrite medium is a nitrite gel medium and the acidic medium is an acidic gel medium.
19 . The composition system of claim 17 , wherein the nitrite medium is a nitrite lotion medium and the acidic medium is an acidic lotion medium.
20 . The composition system of claim 17 , wherein the nitrite medium is a nitrite gel medium and the acidic medium is an acidic lotion medium.
21 . The composition system of claim 17 , wherein the nitrite medium is a nitrite lotion medium and the acidic medium is an acidic gel medium.
22 . The composition system of claim 17 , wherein the dose of nitric oxide has a concentration of nitric oxide of at least approximately 320 ppm of nitric oxide.
23 . The composition system of claim 17 , wherein the nitric oxide topical medium comprises approximately 3 grams of the nitrite medium and approximately 3 grams of the acidic medium thereby providing a concentration of nitric oxide of at least approximately 1000 ppm for topical application.
24 . The composition system of claim 17 , wherein the nitric oxide topical medium is a gel and comprises approximately 3 grams of the nitrite medium and approximately 3 grams of the acidic medium thereby providing a concentration of nitic oxide of at least approximately 840 ppm for topical application.
25 . The composition system of claim 17 , wherein the nitric oxide topical medium is a lotion and comprises approximately 3 grams of the nitrite medium and approximately 3 grams of the acidic medium thereby providing a concentration of nitic oxide of at least approximately 450 ppm for topical application.
26 . (canceled)
27 . The composition system of claim 17 , wherein the nitrite medium comprises less than about 1% by weight of a combination of additives comprising two or more of methylchloroisothiazolinone, methylisothiazolinone, sodium hydroxide, ethylenediamine tetraacetate tetrasodium salt, and citric acid.
28 . The composition system of claim 17 , wherein the acidic medium comprises greater than about 1% hydroxypropyl methylcellulose polymers by weight.
29 . The composition system of claim 17 , wherein the acidic medium comprises less than about 1% by weight of a combination of additives comprising two or more of methylchloroisothiazolinone, methylisothiazolinone, sodium hydroxide, and ethylenediamine tetraacetate tetrasodium salt.