CONTROLLED SYMPATHECTOMY AND MICRO-ABLATION SYSTEMS AND METHODS
A catheter system for controlled sympathectomy procedures is disclosed. A catheter system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed.
1 . A microsurgical tool comprising:
at least one microfinger; and
at least one sensing tip coupled to the at least one microfinger, the at least one sensing tip comprising an isolation layer selectively coated over one or more regions of the at least one sensing tip to expose an electrically conducting material providing one or more electrodes;
wherein the at least one microfinger is configured to bias the at least one sensing tip against a region of a wall of a lumen to interface at least a portion of the exposed electrically conducting material of the at least one sensing tip providing at least one of the one or more electrodes with the wall of the lumen; and
wherein the at least one sensing tip is configured to convey one or more electrophysiological signals, measured by said at least one electrode, associated with electrophysiological activity in the region of the wall of the lumen.
2 . The microsurgical tool of claim 1 , wherein the isolation layer is configured so as to substantially electrically isolate the at least one sensing tip from a cavity of the lumen.
3 . The microsurgical tool of claim 1 , wherein when the at least one microfinger biases the at least one sensing tip against the region of the wall, the exposed electrically conducting material of the at least one sensing tip is isolated from adjacent fluid in the lumen by the isolation layer.
4 . The microsurgical tool of claim 1 , wherein the isolation layer comprises at least one of an oxide layer, a dielectric coating, a polymer layer and a lubricious layer.
5 . The microsurgical tool of claim 1 , wherein the microsurgical tool is configured to utilize a bioimpedance measurement obtained from the at least one sensing tip to determine a state of isolation between the at least one sensing tip and a local fluid in the lumen.
6 . The microsurgical tool of claim 5 , wherein the local fluid in the lumen comprise blood.
7 . The microsurgical tool of claim 1 , wherein the at least one sensing tip comprises at least one core flexure with the isolation layer selectively coated over one or more regions thereof.
8 . The microsurgical tool of claim 7 , wherein the at least one core flexure comprises an electrically conducting superelastic spring-like material, and wherein the isolation layer comprise a radio-opaque coating.
9 . The microsurgical tool of claim 7 , wherein one or more exposed regions of the at least one core flexure are coated with one or more electrode materials.
10 . The microsurgical tool of claim 9 , wherein the one or more electrode materials comprise at least one of a metal, a metal alloy, a conducting polymer, a composite, a carbon material and a conjugated polymer.
11 . The microsurgical tool of claim 9 , wherein the one or more exposed regions of the at least one core flexure are oriented to one side of a neutral axis of the at least one core flexure.
12 . The microsurgical tool of claim 1 , wherein the electrophysiological signals are related to one or more of water concentration, tone, evoked potential, remote stimulation of nervous activity, an electromyographic signal, a mechanomyographic signal, a local field potential, an electroacoustic event, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity, central sympathetic drive, tissue tone, and nerve traffic.
13 . The microsurgical tool of claim 1 , wherein the at least one sensing tip is electrically coupled with a microcircuit, the microcircuit being configured to condition the one or more electrophysiological signals, the microcircuit being embedded into at least one of the sensing tip and the microfinger.
14 . The microsurgical tool of claim 1 , wherein the at least one microfinger is configured so as to substantially maintain contact with the wall of the lumen while the at least one microfinger is swept longitudinally at least one of down the lumen and circumferentially around the lumen.
15 . The microsurgical tool of claim 1 , wherein the at least one microfinger is configured so as to substantially maintain a constant force against the wall of the lumen during relative movement there between.
16 . The microsurgical tool of claim 15 , wherein the at least one microfinger comprises an active material element, the active material element being configured to alter the contact force between the sensing tip and the wall upon receipt of a control signal.
17 . The microsurgical tool of claim 1 , wherein the at least one microfinger is configured so as to be deployed from a delivery catheter.
18 . The microsurgical tool of claim 17 wherein at least a portion of the delivery catheter has a diameter less than 3 millimeters.
19 . The microsurgical tool of claim 1 , wherein the at least one microfinger has a characteristic width of less than 150 micrometers.
20 . The microsurgical tool of claim 19 , wherein the plurality of microfingers are configured to form at least one of a cage, a mesh, and a stent-like structure.