ELECTROSPUN PTFE COATED STENT AND METHOD OF USE
A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.
1 . A vascular prosthesis, comprising:
a scaffolding structure configured to resist radial compression when disposed in a lumen of a patient, and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising a first layer of polytetrafluoroethylene (PTFE) and a tie layer coupled to the first layer, the tie layer impervious to cell migration into the tie layer.
2 . The vascular prosthesis of claim 1 , wherein:
the first layer comprises serially deposited PTFE fibers; and the coating further comprises a second layer of PTFE.
3 . The vascular prosthesis of claim 2 , wherein the serially deposited PTFE fibers are electrospun PTFE fibers.
4 . The vascular prosthesis of claim 1 , wherein the first layer is permeable to cell migration into the first layer.
5 . The medical appliance of claim 1 , wherein the first layer defines a luminal surface of the vascular prosthesis.
6 . The vascular prosthesis of claim 1 , wherein the tie layer is non-porous and non-fibrous.
7 . The vascular prosthesis of claim 2 , wherein the second layer is permeable to cell migration into the second layer.
8 . The vascular prosthesis of claim 2 , wherein the second layer comprises serially deposited PTFE fibers.
9 . The vascular prosthesis of claim 2 , wherein the second layer comprises electrospun PTFE fibers.
10 . A medical appliance, comprising:
a scaffolding structure comprising a single wire, and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising:
a first layer of electrospun PTFE fibers;
a tie layer of fluorinated ethylene propylene (FEP) coupled to the first layer; and
a second layer of PTFE.
11 . The medical appliance of claim 10 , wherein the first layer defines a luminal surface of the medical appliance.
12 . The medical appliance of claim 10 , wherein the first layer is permeable to cell migration into the first layer.
13 . The medical appliance of claim 10 , wherein the tie layer is impervious to cell migration into the tie layer.
14 . The medical appliance of claim 10 , wherein the tie layer is non-porous and non-fibrous.
15 . The medical appliance of claim 10 , wherein the second layer comprises electrospun PTFE fibers.
16 . A medical stent, comprising:
a scaffolding structure comprising a wave configuration, and
a coating disposed on at least a portion of the scaffolding structure, the coating comprising:
an inner layer of electrospun PTFE fibers;
a tie layer of FEP coupled to the first layer and impervious to cell migration into the tie layer; and
an outer layer of electrospun PTFE fibers.
17 . The medical stent of claim 16 , wherein the inner layer defines a luminal surface of the medical appliance.
18 . The medical stent of claim 16 , wherein the inner layer is permeable to cell migration into the inner layer.
19 . The medical stent of claim 16 , wherein the tie layer is non-porous and non-fibrous.
20 . The medical stent of claim 16 , wherein the outer layer is permeable to cell migration into the outer layer.