GIP/GLP1 AGONIST COMPOSITIONS
A composition of tirzepatide, comprising an agent selected from NaCl and propylene glycol; and dibasic sodium phosphate is provided.
1 - 43 . (canceled)
44 . A pharmaceutical composition comprising:
(a) tirzepatide, or a pharmaceutically acceptable salt thereof; and
(b) from about 6.2 mg/mL to about 9.5 mg/mL of NaCl, wherein the pharmaceutical composition has a pH of from about 6.5 to about 7.5 and the composition is free of preservative.
45 . The pharmaceutical composition of claim 44 , wherein the composition comprises from about 7.0 mg/mL to about 9.0 mg/mL of NaCl.
46 . The pharmaceutical composition of claim 45 , wherein the composition comprises about 8.2 mg/mL of NaCl.
47 . The pharmaceutical composition of claim 44 , wherein the composition has a pH of from about 6.7 to about 7.3.
48 . The pharmaceutical composition of claim 44 , wherein the composition comprises from about 5 mg/mL to about 30 mg/mL of tirzepatide, or a pharmaceutically acceptable salt thereof.
49 . The pharmaceutical composition of claim 48 , wherein the composition comprises 5 mg/mL, 10 mg/mL, 15 mg/mL, 20 mg/mL, 25 mg/mL, or 30 mg/mL of tirzepatide, or a pharmaceutically acceptable salt thereof.
50 . The pharmaceutical composition of claim 44 , wherein the composition is administered using an automatic injection apparatus.
51 . The pharmaceutical composition of claim 44 , wherein the preservative is selected from the group consisting of metacresol and phenol.