BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
1 . A method of treating depression comprising: orally administering a dosage form once a day or twice a day to a human being suffering from depression; wherein the dosage form comprises dextromethorphan or a pharmaceutically acceptable salt thereof, and citalopram or a pharmaceutically acceptable salt thereof; wherein the dextromethorphan and the citalopram are the only therapeutically active agents in the dosage form; and wherein the human being is an extensive metabolizer of dextromethorphan.
2 . The method of claim 1 , wherein the dosage form is orally administered for at least 8 consecutive days.
3 . The method of claim 1 , wherein the depression is major depressive disorder.
4 . The method of claim 1 , wherein the depression is treatment resistant depression.
5 . The method of claim 1 , wherein the dosage form comprises about 10 mg to about 20 mg of the citalopram.
6 . The method of claim 1 , wherein the dosage form is orally administered for at least 14 consecutive days.
7 . The method of claim 1 , wherein the dosage form provides immediate release of the dextromethorphan.
8 . The method of claim 1 , wherein the dosage form provides sustained release of the citalopram.
9 . The method of claim 1 , wherein the dosage form contains about 20 mg to about 50 mg of the dextromethorphan.
10 . The method of claim 1 , wherein the dosage form contains about 30 mg to about 60 mg of the dextromethorphan.
11 . The method of claim 1 , wherein the dosage form contains about 40 mg to about 50 mg of the dextromethorphan.
12 . The method of claim 1 , wherein the dosage form contains about 50 mg to about 70 mg of the dextromethorphan.
13 . The method of claim 1 , wherein the dosage form contains about 70 mg to about 100 mg of the dextromethorphan.
14 . The method of claim 1 , wherein the dosage form contains about 45 mg of a dextromethorphan salt.
15 . The method of claim 1 , wherein the dextromethorphan comprises a deuterium-modified dextromethorphan.
16 . The method of claim 1 , wherein the dosage form is a capsule, a tablet, or a solution.
17 . The method of claim 1 , wherein a dextromethorphan plasma level is increased as compared to administering the dextromethorphan alone.
18 . The method of claim 1 , wherein the human being is converted to a poor metabolizer of dextromethorphan.
19 . The method of claim 1 , wherein the dosage form further comprises a pharmaceutically acceptable excipient.
20 . The method of claim 1 , wherein the elimination half-life of dextromethorphan increases upon orally administering the dosage form.