TISSUE SUBSTITUTE MATERIALS AND METHODS FOR TISSUE REPAIR
Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.
1 . A resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, wherein the first and second non-woven fiber compositions each independently comprise a polymer selected from the group consisting of polymers and copolymers of lactic and glycolic acids, poly(ether-co-esters), poly(hydroxybutyrate), polycaprolactone, copolymers of lactic acid and ε-aminocapronic acid, lactide polymers, copolymers of poly(hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid, poly(N-acetyl-D-glucosamine), polydioxanone, cross-linked hyaluronic acid, cross-linked collagen, poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), poly(lactide-co-glycolide), poly(L-lactide), poly(D,L-lactide), poly(ethylene glycol), montmorillonite, poly(L-lactide-co-ε-caprolactone), poly(ε-caprolactone-co-ethyl ethylene phosphate), poly[bis(p-methylphenoxy)phosphazene], poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(ester urethane) urea, polyurethane, polyethylene terephthalate, poly(p-dioxanone), poly(ethylene oxide), poly(phosphazene), poly(ethylene-co-vinylacetate), poly(ethylene-co-vinyl alcohol), poly(ethylenimine), poly(ethyleneoxide), polyvinylpyrrolidone, polystyrene, and combinations thereof;
wherein the resorbable fiber matrix comprises:
a plurality of pores,
a plurality of protrusions,
a plurality of depressions; and
an architecture resembling a native extracellular matrix.
2 . The resorbable fiber matrix of claim 1 , wherein the first non-woven fiber composition to the second non-woven fiber composition ratio ranges from about 10:1 to about 1:10.
3 . The resorbable fiber matrix of claim 3 , wherein the plurality of protrusions comprise a substantially uniform height or depth.
4 . The resorbable fiber matrix of claim 3 , wherein one or more of the plurality of protrusions or plurality of depressions form a pattern.
5 . The resorbable fiber matrix of claim 3 , wherein one or more of the plurality of protrusions or plurality of depressions are randomly distributed.
6 . The resorbable fiber matrix of claim 1 , wherein the resorbable fiber matrix comprises a tensile strength from about 1 Newton to about 15 Newtons.
7 . The resorbable fiber matrix of claim 1 , wherein the resorbable fiber matrix comprises a suture pull-out strength from about 1 Newton to about 5 Newtons of force.
8 . The resorbable fiber matrix of claim 1 , wherein the resorbable fiber matrix comprises a first surface and a second surface, wherein the first surface and the second surface have a different average fiber density.
9 . The resorbable fiber matrix of claim 1 , wherein the first non-woven fiber composition comprises poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), or combinations thereof.
10 . The resorbable fiber matrix of claim 9 , wherein the second non-woven fiber composition comprises polycaprolactone, poly(L-lactide-co-ε-caprolactone), poly(p-dioxanone, or combinations thereof.
11 . The resorbable fiber matrix of claim 10 , wherein the first non-woven fiber composition comprises poly(lactic-co-glycolic acid) and the second fiber composition comprises poly(dioxanone).
12 . A resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, wherein the first and second non-woven fiber compositions each independently comprise a polymer selected from the group consisting of polymers and copolymers of lactic and glycolic acids, poly(ether-co-esters), poly(hydroxybutyrate), polycaprolactone, copolymers of lactic acid and ε-aminocapronic acid, lactide polymers, copolymers of poly(hydroxybutyrate) and 3-hydroxyvalerate, polyesters of succinic acid, poly(N-acetyl-D-glucosamine), polydioxanone, cross-linked hyaluronic acid, cross-linked collagen, poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), poly(lactide-co-glycolide), poly(L-lactide), poly(D,L-lactide), poly(ethylene glycol), montmorillonite, poly(L-lactide-co-ε-caprolactone), poly(ε-caprolactone-co-ethyl ethylene phosphate), poly[bis(p-methylphenoxy) phosphazene], poly(3-hydroxybutyrate-co-3-hydroxyvalerate), poly(ester urethane) urea, polyurethane, polyethylene terephthalate, poly(p-dioxanone), poly(ethylene oxide), poly(phosphazene), poly(ethylene-co-vinylacetate), poly(ethylene-co-vinyl alcohol), poly(ethylenimine), poly(ethyleneoxide), polyvinylpyrrolidone, polystyrene, and combinations thereof;
wherein:
the resorbable fiber matrix comprises a plurality of pores comprising a mean pore size of from about 10 μm 2 to about 10,000 μm 2 ,
the first non-woven fiber composition and the second non-woven fiber composition each have a mean fiber diameter of less than 5 μm, and
the resorbable fiber matrix comprises an architecture resembling a native extracellular matrix.
13 . The resorbable fiber matrix of claim 12 , wherein the first non-woven fiber composition to the second non-woven fiber composition ratio ranges from about 10:1 to about 1:10.
14 . The resorbable fiber matrix of claim 12 , wherein the pores comprise a mean pore size of less than about 300 μm 2 .
15 . The resorbable fiber matrix of claim 12 , wherein one or more of the first non-woven fiber composition and the second non-woven fiber composition comprise a mean fiber diameter of less than about 1 μm.
16 . The resorbable fiber matrix of claim 12 , wherein the pores are interconnected.
17 . The resorbable fiber matrix of claim 12 , wherein the pore size is configured to promote cellular infiltration, growth, and proliferation of cells.
18 . The resorbable fiber matrix of claim 12 , wherein the first non-woven fiber composition comprises poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), or combinations thereof.
19 . The resorbable fiber matrix of claim 18 , wherein the second non-woven fiber composition comprises polycaprolactone, poly(L-lactide-co-&-caprolactone), poly(p-dioxanone, or combinations thereof.
20 . The resorbable fiber matrix of claim 19 , wherein the first non-woven fiber composition comprises poly(lactic-co-glycolic acid) and the second fiber composition comprises poly(dioxanone).