FLUID FOR ACCOMMODATING INTRAOCULAR LENSES
Fluids incorporated into intraocular lenses and their methods of use. In some embodiments the fluids are silicone oils, and in some embodiments they are used in accommodating intraocular lenses.
1 . A method of manufacturing an intraocular lens, comprising:
assembling the intraocular lens using in part a bulk polymeric material; and
introducing a silicone oil into a fluid chamber defined within the intraocular lens, wherein the silicone oil has a polydispersity index of less than 1.5.
2 . The method of claim 1 , further comprising synthesizing and purifying the silicone oil to be introduced into the fluid chamber of the intraocular lens.
3 . The method of claim 2 , wherein synthesizing the silicone oil further comprises synthesizing the silicone oil using a living polymerization reaction.
4 . The method of claim 2 , wherein purifying the silicone oil further comprises purifying the silicone oil using supercritical CO 2 extraction.
5 . The method of claim 1 , wherein the intraocular lens is a fluid-driven accommodating intraocular lens.
6 . The method of claim 1 , wherein the silicone oil has a mean molecular weight of between 5000 Daltons and 6500 Daltons.
7 . The method of claim 1 , wherein a refractive index of the silicone oil is substantially the same as the refractive index of the bulk polymeric material, wherein the intraocular lens further comprises an optic portion, and wherein the optic portion is made in part of the bulk polymeric material, wherein the fluid chamber is within the optic portion.
8 . A method of manufacturing a silicone oil for use in an intraocular lens, comprising:
synthesizing the silicone oil to be used in the intraocular lens using a living polymerization reaction; and
purifying the silicone oil.
9 . The method of claim 8 , wherein the silicone oil is synthesized using at least one of an anionic and a cationic living polymerization reaction.
10 . The method of claim 8 , wherein the silicone oil is synthesized as branched polymeric structures.
11 . The method of claim 10 , wherein the branched polymeric structures comprises a star-like polymeric structure.
12 . The method of claim 10 , wherein the branched polymeric structures comprises a comb-like polymeric structure.
13 . The method of claim 10 , wherein the branched polymeric structures comprises an X-shaped polymeric structure.
14 . The method of claim 8 , wherein synthesizing the silicone oil further comprises synthesizing the silicone oil using a base catalyzed ring opening reaction.
15 . The method of claim 8 , wherein synthesizing the silicone oil further comprises synthesizing the silicone oil using condensation of dialkyldichloro silanes with water.
16 . The method of claim 8 , wherein purifying the silicone oil further comprises purifying the silicone oil using supercritical CO 2 extraction.
17 . The method of claim 8 , wherein purifying the silicone oil further comprises purifying the silicone oil using wiped-film extraction.
18 . The method of claim 8 , further comprising purifying the silicone oil until the silicone oil has a mean molecular weight of between 5000 Daltons and 6500 Daltons.
19 . The method of claim 8 , further comprising purifying the silicone oil until no more than 20 wt % of the silicone oil is comprised of components below 4000 Daltons.
20 . The method of claim 8 , further comprising purifying the silicone oil until no more than 10 wt % of the silicone oil is comprised of components below 3000 Daltons.