METHOD OF TREATING AMYOTROPHIC LATERAL SCLEROSIS WITH PRIDOPIDINE

1 . A method for treating a subject afflicted with amyotrophic lateral sclerosis (ALS), comprising periodically administering to the subject a composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof and at least one pridopidine's analog or pharmaceutically acceptable salt thereof of compounds of Formula 1 and 4:

2 . The method of claim 1 , wherein the composition comprises pridopidine or pharmaceutically acceptable salt thereof and compound 1 or pharmaceutically acceptable salt thereof.

3 . The method of claim 1 , wherein the composition comprises pridopidine or pharmaceutically acceptable salt thereof and compound 4 or pharmaceutically acceptable salt thereof.

4 . The method of claim 1 , wherein the composition comprises pridopidine or pharmaceutically acceptable salt thereof and compound 1 and compound 4 or pharmaceutically acceptable salt thereof.

5 . The method of claim 1 , wherein the method is effective for maintaining, improving, or lessening the decline of symptoms associated with ALS in a subject in need thereof; and decreasing the risk of death or prolonging the survival of a subject with ALS; wherein the symptom is impaired: functionality, respiratory function, bulbar function, speech, muscle strength, increase of neurofilament light chain (NfL), elevation in anti-inflammatory biomarkers or any combination thereof, wherein the method comprises administering to the subject a composition comprising a therapeutically acceptable amount of pridopidine or pharmaceutically acceptable salt thereof.

6 . The method of claim 5 , wherein the impairment of muscle strength comprises reduced muscles stiffness, muscle weakness, muscle wasting, muscle cramps, difficulty speaking, difficulty swallowing, difficulty breathing, difficulty chewing, difficulty walking, fasciculations, and/or worsening posture.

7 . The method of claim 5 , wherein ALS patient's impaired functionality comprises, salivation, swallowing, handwriting, cutting food and handling utensils, dressing and hygiene, turning in bed and adjusting bed clothes, walking, climbing stairs, dyspnea, orthopnea, respiratory insufficiency or any combination thereof.

8 . The method of claim 5 , wherein the impairment of speech comprises reduced speaking rate, reduced phonation time, Articulatory Precision impaired Minimum Monotonicity, impaired pause rate ratio, regulatory of voicing ration, reduced articulation rate, reduced articulation precision, impaired intelligibility, impaired naturalness, and impaired listener effort.

9 . The method of claim 1 , wherein said subject has faster disease progression as measured by the ALSFRS-R pre-baseline slope.

10 . The method of claim 1 , wherein said subject has faster disease progression as measured by the baseline NfL levels.

11 . The method of claim 1 , wherein said subject has early ALS with less than 18 months from symptom onset or with less than 24 months from symptom onset.

12 . The method of claim 1 , wherein said subject has faster disease progression as measured by the ALSFRS-R pre-baseline slope and early with <18 or <24 months from symptom onset.

13 . The method of claim 1 , wherein the composition is administered daily, twice a week, three times a week or more often than once daily.

14 . The method of claim 1 , wherein the amount of pridopidine or pharmaceutically acceptable salt thereof is administered daily, twice daily, twice a week, three times a week or more often than once daily.

15 . The method of claim 1 , wherein composition is administered orally.

16 . The method of claim 1 , wherein the amount of pridopidine administered is 10 mg per day to 90 mg per day.

17 . The method of any one of claim 1 , wherein the salt of pridopidine or of pridopidine's analog compound is selected from the group consisting from hydrochloride, hydrobromide, hydroiodide, nitrate, perchlorate, phosphate, acid-phosphate, sulphate, bisulfate, formate, gluconate, glucaronate, saccharate, isonicotinate, acetate, aconate, ascorbate, benzenesulphonate, benzoate, cinnamate, citrate, embonate, enantate, fumarate, glutamate, glycolate, lactate, maleate, gentisinate, malonate, mandelate, methanesulfonate, ethanesulfonate, naphthalene-2-sulphonate, phthalate, salicylate, sorbate, stearate, succinate, tartrate, pantothenate, bitartrate, and toluene-p-sulfonate, pamoate (i.e., 1,1′-methylene-bis-(2-hydroxy-3-naphthoate)) salt.

18 . The method of claim 17 , wherein the pridopidine salt is pridopidine hydrochloride.

19 . The method of claim 1 , wherein the subject is a human subject.

20 . The method of claim 1 , further comprising administering to the subject a second composition comprising a therapeutically effective amount of a second compound, wherein the second compound is riluzole, edaravone, dextromethorphan/quinidine, SLS-005 (Trehalose), DNL343, CNM-Au8 nanocrystalline gold or ABBV-CLS-7262.