TISSUE SUBSTITUTE MATERIALS AND METHODS FOR TISSUE REPAIR
Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.
1 - 20 . (Canceled)
21 . A resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, wherein the first and second non-woven fiber compositions each independently comprise a resorbable polymer;
wherein the resorbable fiber matrix comprises:
a plurality of pores,
a plurality of protrusions,
a plurality of depressions, and
an architecture resembling a native extracellular matrix;
wherein:
the first and second non-woven fiber compositions are configured to break down into one or more acidic byproducts when applied to a tissue site, and
the one or more acidic byproducts are selected from the group consisting of monomers and oligomers comprising: lactic acid, glycolic acid, 6-hydroxycaproic acid, caproic acid, 4-hydroxybutyrate, 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
22 . The resorbable fiber matrix of claim 21 , wherein the first non-woven fiber composition to the second non-woven fiber composition ratio ranges from about 10:1 to about 1:10.
23 . The resorbable fiber matrix of claim 21 , wherein the first and second non-woven fiber compositions are commingled.
24 . The resorbable fiber matrix of claim 21 , wherein the first and second non-woven fiber compositions are configured to break down into one or more acidic byproducts via hydrolysis.
25 . The resorbable fiber matrix of claim 21 , wherein the one or more acidic byproducts create an acidic microenvironment, wherein the acidic microenvironment is configured to perform a function selected from the group consisting of: promote cell growth, promote antimicrobial activity, promote angiogenesis, modulate cellular and pathogenic activity, improve tissue oxygenation, promote epithelialization, promote the proliferation of fibroblasts, and migration of fibroblasts.
26 . The resorbable fiber matrix of claim 25 , wherein the acidic microenvironment is configured to promote cell growth, wherein promoting cell growth results in granulation tissue formation and/or neovascularization.
27 . The resorbable fiber matrix of claim 26 , wherein the first non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: lactic acid and glycolic acid.
28 . The resorbable fiber matrix of claim 27 , wherein the second non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: 6-hydroxycaproic acid, caproic acid, 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
29 . The resorbable fiber matrix of claim 28 , wherein the second non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
30 . A resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, wherein the first and second non-woven fiber compositions each independently comprise a resorbable polymer;
wherein:
the resorbable fiber matrix comprises a plurality of pores comprising a mean pore size of from about 10 μm 2 to about 10,000 μm 2 ,
the first non-woven fiber composition and the second non-woven fiber composition each have a mean fiber diameter of less than 5 μm,
the resorbable fiber matrix has an architecture resembling a native extracellular matrix,
the first and second non-woven fiber compositions are configured to break down into one or more acidic byproducts when applied to a tissue site, and
the one or more acidic byproducts are selected from the group consisting of monomers and oligomers comprising: lactic acid, glycolic acid, 6-hydroxycaproic acid, caproic acid, 4-hydroxybutyrate, 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
31 . The resorbable fiber matrix of claim 30 , wherein the first non-woven fiber composition to the second non-woven fiber composition ratio ranges from about 10:1 to about 1:10.
32 . The resorbable fiber matrix of claim 30 , wherein the first and second non-woven fiber compositions are commingled.
33 . The resorbable fiber matrix of claim 30 , wherein the first and second non-woven fiber compositions are configured to break down into one or more acidic byproducts via hydrolysis.
34 . The resorbable fiber matrix of claim 30 , wherein the one or more acidic byproducts create an acidic microenvironment, wherein the acidic microenvironment is configured to perform a function selected from the group consisting of: promote cell growth, promote antimicrobial activity, promote angiogenesis, modulate cellular and pathogenic activity, improve tissue oxygenation, promote epithelialization, promote the proliferation of fibroblasts, and migration of fibroblasts.
35 . The resorbable fiber matrix of claim 34 , wherein the acidic microenvironment is configured to promote cell growth, wherein promoting cell growth results in granulation tissue formation and/or neovascularization.
36 . The resorbable fiber matrix of claim 30 , wherein the first non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: lactic acid and glycolic acid.
37 . The resorbable fiber matrix of claim 36 , wherein the second non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: 6-hydroxycaproic acid, caproic acid, 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
38 . The resorbable fiber matrix of claim 37 , wherein the second non-woven fiber composition is configured to break down into one or more acidic byproducts selected from the group consisting of monomers and oligomers comprising: 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
39 . The resorbable fiber matrix of claim 30 , wherein the resorbable fiber matrix comprises interconnecting pores.
40 . The resorbable fiber matrix of claim 30 , wherein the pore size is configured to promote cellular infiltration, growth, and/or proliferation.