TISSUE SUBSTITUTE MATERIALS AND METHODS FOR TISSUE REPAIR
Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.
1 - 20 . (canceled)
21 . A method of tissue repair in an individual in need thereof, comprising:
implanting a resorbable fiber matrix at a surgical site, the resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, the first and second non-woven fiber compositions each independently comprising a resorbable polymer;
wherein:
the resorbable fiber matrix has an architecture resembling a native extracellular matrix,
the resorbable fiber matrix has a tensile strength from about 1 Newton to about 15 Newtons, and
the implanted resorbable fiber matrix reinforces soft tissue where weakness exists.
22 . The method of claim 21 , wherein the resorbable fiber matrix is configured to resorb following tissue regeneration.
23 . The method of claim 21 , further comprising closing the surgical site after implantation.
24 . The method of claim 21 , further comprising securing the resorbable fiber matrix to the surgical site after implantation.
25 . The method of claim 24 , wherein the resorbable fiber matrix is secured to the surgical site by suture.
26 . The method of claim 21 , further comprising cutting the resorbable fiber matrix to fit the surgical site prior to implantation.
27 . The method of claim 21 , further comprising hydrating the resorbable fiber matrix prior to implantation.
28 . The method of claim 21 , wherein the resorbable fiber matrix comprises a plurality of pores comprising a mean pore size of from about 10 m 2 to about 300 m 2 .
29 . The method of claim 21 , wherein the first non-woven fiber composition and the second non-woven fiber composition each have a mean fiber diameter of less than 5 μm.
30 . The method of claim 21 , wherein the first non-woven fiber composition comprises poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), or combinations thereof.
31 . The method of claim 30 , wherein the second non-woven fiber composition comprises polycaprolactone, poly(L-lactide-co-p-caprolactone), poly(dioxanone), or combinations thereof.
32 . The method of claim 31 , wherein the first non-woven fiber composition comprises poly(lactic-co-glycolic acid) and the second non-woven fiber composition comprises poly(dioxanone).
33 . The method of claim 24 , wherein the first and second non-woven fiber compositions are configured to break down into one or more acidic byproducts when applied to a tissue site, and the one or more acidic byproducts are selected from the group consisting of monomers and oligomers comprising: lactic acid, glycolic acid, 6-hydroxycaproic acid, caproic acid, 4-hydroxybutyrate, 2-hydroxyethoxyacetic acid, glyoxylic acid, and oxalic acid.
34 . A resorbable fiber matrix comprising:
a first non-woven fiber composition and a second non-woven fiber composition, wherein the first and second non-woven fiber compositions each independently comprise a resorbable polymer;
wherein:
the resorbable fiber matrix has an architecture resembling a native extracellular matrix,
the resorbable fiber matrix has a tensile strength from about 1 Newton to about 15 Newton, and
the resorbable fiber matrix is configured for implantation to reinforce soft tissue where weakness exists.
35 . The resorbable fiber matrix of claim 34 , wherein the resorbable fiber matrix is configured to resorb following tissue regeneration.
36 . The resorbable fiber matrix of claim 34 , wherein the resorbable fiber matrix comprises a plurality of pores comprising a mean pore size of from about 10 μm 2 to about 300 m 2 .
37 . The resorbable fiber matrix of claim 34 , wherein the first non-woven fiber composition and the second non-woven fiber composition each have a mean fiber diameter of less than 5 m.
38 . The resorbable fiber matrix of claim 34 , wherein the first non-woven fiber composition comprises poly(glycolic acid), poly(L-lactic acid), poly(lactic-co-glycolic acid), or combinations thereof.
39 . The resorbable fiber matrix of claim 38 , wherein the second non-woven fiber composition comprises polycaprolactone, poly(L-lactide-co-F-caprolactone), poly(dioxanone), or combinations thereof.
40 . The resorbable fiber matrix of claim 39 , wherein the first non-woven fiber composition comprises poly(lactic-co-glycolic acid) and the second non-woven fiber composition comprises poly(dioxanone).