LUBRICIOUS COATING FOR MEDICAL DEVICE
Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.
1 . A liquid coating composition for coating a medical device, the composition comprising a first polymer that is an acrylic acid polymer, a second polymer that is an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups, wherein the liquid coating composition has a pH of less than about 6.
2 . The liquid coating composition of claim 1 having a pH in the range of pH 2-6, or in the range of pH 3-5.
3 . The liquid coating composition of claim 1 comprising water and an alcohol, wherein the alcohol is present in an amount in the range of 5-45% (v/v) in the liquid coating composition.
4 . The liquid coating composition of claim 1 , wherein the acrylic acid polymer is an acrylic acid homopolymer.
5 . The liquid coating composition of claim 1 wherein the second polymer comprises acrylamide-2-acrylamido-2-methylpropanesulfonate (AMPS)- and poly(ethylene glycol)-containing subunits.
6 . The liquid coating composition of claim 1 , wherein first polymer is present in an amount in the range of 20 to 80% (wt) and the second polymer is present in an amount in the range of 10 to 60% (wt) of solids components in the liquid coating composition, and the first and second polymers constitute about 90% (wt) or greater, 95% (wt) or greater, 98% (wt) or greater, or 100% (wt) of the polymeric materials of the coating composition.
7 . The liquid coating composition of claim 6 , wherein first polymer is present in an amount in the range of 30 to 70% (wt), or 40 to 60% (wt), and the second polymer is present in an amount in the range of 10 to 60% (wt) of solids components in the liquid coating composition, and the first and second polymers constitute about 98% (wt) or greater, or 100% (wt) of the polymeric materials of the coating composition.
8 . The liquid coating composition of claim 1 wherein the cross-linking agent is a compound of a formula selected from:
wherein R 1 , R 2 , R 8 and R 9 are any substitution; R 3 , R 4 , R 6 and R 7 are alkyl, aryl, or a combination thereof; R 5 is any substitution; and each X, independently, is O, N, Se, S, or alkyl, or a combination thereof;
wherein R 1 and R 5 are any substitution; R 2 and R 4 can be any substitution, except OH; R 3 can be alkyl, aryl, or a combination thereof; and each X, independently, is O, N, Se, S, alkyl or a combination thereof;
wherein R 1 , R 2 , R 4 and R 5 are any substitution; R 3 is any substitution; R 6 and R 7 are alkyl, aryl, or a combination thereof; and each X, independently, is O, N. Se, S, alkyl, or a combination thereof, and
9 . A medical device comprising a lubricious coating, wherein the lubricous coating is formed from the liquid coating composition of claim 1 .
10 . The medical device of claim 9 comprising a catheter.
11 . A method for treating a subject comprising inserting the medical device comprising the lubricious coating of claim 9 into the subject.
12 . A method for forming a coating on a medical device comprising applying the liquid coating composition of claim 1 on a medical device surface.
13 . The method of claim 12 comprising steps of (a) dip coating a medical device in the liquid coating composition, (b) at least partially drying the coting, and (c) irradiating the coating with UV light.
14 . The method of claim 12 further comprising contacting the coated medical device with a liquid composition comprising sodium bicarbonate.
15 . The method of claim 12 wherein the medical device is a catheter.