SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS
Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.
1 . A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
2 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
3 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
4 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
5 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
6 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
7 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
8 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, having the following structure:
9 . The compound of claim 1 , wherein the compound is in the form of a hydrochloride salt.
10 . The compound of claim 2 , wherein the compound is in the form of a hydrochloride salt.
11 . The compound of claim 3 , wherein the compound is in the form of a hydrochloride salt.
12 . The compound of claim 4 , wherein the compound is in the form of a hydrochloride salt.
13 . The compound of claim 5 , wherein the compound is in the form of a hydrochloride salt.
14 . The compound of claim 6 , wherein the compound is in the form of a hydrochloride salt.
15 . The compound of claim 7 , wherein the compound is in the form of a hydrochloride salt.
16 . The compound of claim 8 , wherein the compound is in the form of a hydrochloride salt.