APPARATUS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA UTILIZING CRYOLYSIS OF ADIPOSE TISSUES
Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.
1 . A device for treatment of obstructive sleep apnea, comprising:
a shaft;
an engagement member disposed at a distal end of the shaft and having a contact surface shaped to be complementary to an oropharyngeal tissue target and to cool the oropharyngeal tissue target;
a sensor disposed on the engagement member;
a cooling unit;
a lumen disposed in the shaft and in communication with the engagement member and the cooling unit to circulate a cooling fluid through the engagement member; and
a processor operatively coupled to the cooling unit and the sensor, the processor being configured to responsively adjust a temperature of the cooling fluid with the cooling unit to achieve and maintain a desired temperature of the engagement member sufficient to cause cryolysis of adipose tissue within the oropharyngeal tissue target.
2 . The device of claim 1 , further comprising a coupler adapted to detachably connect the lumen to the cooling unit to receive the cooling fluid into the lumen and return the cooling fluid from the lumen to the cooling unit.
3 . The device of claim 2 , wherein the shaft includes at least one releasably engageable port communicating with the lumen, the at least one releasably engageable port being configured to detachably connect to the cooling unit via the coupler.
4 . The device of claim 1 , wherein the engagement member comprises a flexible and conformal material.
5 . The device of claim 1 , wherein the engagement member further comprises a hinge.
6 . The device of claim 1 , wherein the engagement member comprises a substantially flat plate.
7 . The device of claim 1 , wherein the engagement member comprises a “C”-shaped member configured to be complementary to a base of a tongue.
8 . The device of claim 1 , wherein the engagement member comprises a “V”-shaped member configured to engage a soft palate or a uvula.
9 . The device of claim 1 , wherein the cooling unit is configured to provide suction to the engagement member to enhance mechanical contact thereof with the oropharyngeal tissue target.
10 . The device of claim 1 , wherein the cooling fluid comprises a liquid.
11 . The device of claim 10 , wherein the liquid comprises a refrigerant.
12 . The device of claim 10 , wherein the liquid comprises a water and glycerine solution.