System and method for analyte measurement
View Patent ↗A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
1. An instrument for determining concentration of glucose in a blood sample, comprising:
a display;
first and second terminals for contacting complimentary first and second terminals of an electrochemical cell adapted to receive a blood sample;
an assessment controller configured and arranged to:
detect deposit of the sample in the cell;
determine sufficiency of volume of the deposited sample;
determine a correction value based on an electrical response from the cell;
obtain an indicated glucose concentration by assessing a reaction of glucose in the blood sample with a chemistry provided in the cell;
apply the correction value to the indicated glucose concentration to arrive at an actual glucose concentration, the actual glucose concentration comprising a compensated indication of the glucose concentration; and
display the actual glucose concentration on the display no more than 10 seconds from the detection of deposit of the sample.
2. The instrument of claim 1 , wherein the determine sufficiency of volume step further comprises the steps of:
applying a first signal to at least one of the first and second terminals of the electrochemical cell;
measuring a first response to the first signal.
3. The instrument of claim 2 , wherein the first test signal comprises a signal having an AC component.
4. The instrument of claim 3 , wherein the first test signal comprises an AC signal.
5. The instrument of claim 1 , wherein the determine a correction value step further comprises the steps of:
applying a first signal to at least one of the first and second terminals of the electrochemical cell;
measuring a first response to the first signal.
6. The instrument of claim 5 , wherein the first test signal comprises a signal having an AC component.
7. The instrument of claim 6 , wherein the first test signal comprises an AC signal.
8. The instrument of claim 1 , wherein the obtain an indicated glucose concentration step further comprises the steps of:
applying a first signal to at least one of the first and second terminals of the electrochemical cell;
measuring a first response to the first signal.
9. The instrument of claim 8 , wherein the first test signal comprises a signal having an AC component.
10. The instrument of claim 9 , wherein the first test signal comprises an AC signal.
11. The instrument of claim 1 , wherein the actual glucose concentration is correlated with the glucose in the blood sample by at least r 2 =0.9400.
12. The instrument of claim 11 , wherein the actual glucose concentration is correlated with the glucose in the blood sample by at least r 2 =0.9800.
13. The instrument of claim 12 , wherein the actual glucose concentration is correlated with the glucose in the blood sample by at least r 2 =0.9900.