Methods of collagen imaging
View Patent ↗Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
1. A diagnostic composition comprising a compound having the following formula, or a pharmaceutically acceptable salt thereof:
[EMTG] n -[L] m -[C] p
wherein m and p are independently one to ten;
wherein n is one to five;
wherein C is a physiologically compatible metal chelating group;
wherein L is a linker; and
wherein EMTG is an Extracellular Matrix Targeting Group, wherein said EMTG comprises a cyclic peptide comprising an amino acid sequence selected from:
(SEQ. ID NO. 828)
W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G;
(SEQ. ID NO. 829)
G-W-H-C-Y-T-Y-F-P-H-H-Y-C-T-Y-G;
(SEQ. ID NO. 830)
A-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G;
(SEQ. ID NO. 831)
L-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G; and
(SEQ. ID NO. 832)
Y-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G,
wherein the C-terminus of the peptide may be amidated or any of the amino acids may be protected, and wherein the peptide has a length of 16 to 30 amino acids.
2. A diagnostic composition comprising a compound having the following formula, or a pharmaceutically acceptable salt thereof:
[EMTG] n -[L] m -[C] p
wherein m and p are independently one to ten;
wherein n is one to five;
wherein C is a physiologically compatible metal chelating group;
wherein L is a linker; and
wherein EMTG is an Extracellular Matrix Targeting Group, wherein said EMTG comprises a cyclic peptide comprising an amino acid sequence selected from:
C-T-T-S-F-P-H-H-Y-C,
(SEQ ID NO: 817)
C-T-T-K-F-P-H-H-Y-C,
(SEQ ID NO: 818)
C-Y-T-Y-F-P-H-H-Y-C,
(SEQ ID NO: 819)
C-T-T-R-F-P-H-H-Y-C,or
(SEQ ID NO: 820)
C-S-G-D-E-Y-T-W-H-C.
(SEQ ID NO: 821)
wherein the C-terminus of the peptide may be amidated or any of the amino acids may be protected, and wherein the peptide has a length of 10 to 30 amino acids.
3. A diagnostic composition comprising a compound having the structure of Compound ID 800
or a pharmaceutically acceptable salt thereof.
4. A diagnostic composition comprising a compound having the structure of Compound ID 801
or a pharmaceutically acceptable salt thereof.
5. A diagnostic composition comprising a compound having the structure of Compound ID 802
or a pharmaceutically acceptable salt thereof.
6. A diagnostic composition comprising a compound having the structure of Compound ID 803
or a pharmaceutically acceptable salt thereof.
7. A diagnostic composition comprising a compound having the structure of Compound ID 807
or a pharmaceutically acceptable salt thereof.
8. A diagnostic composition comprising a compound having the structure of Compound ID 808
or a pharmaceutically acceptable salt thereof.
9. A diagnostic composition comprising a compound having the structure of Compound ID 816
or a pharmaceutically acceptable salt thereof.
10. A diagnostic composition comprising a compound having the structure of Compound ID 813
or a pharmaceutically acceptable salt thereof.
11. A diagnostic composition comprising a compound having the structure of Compound ID 815
or a pharmaceutically acceptable salt thereof.
12. A diagnostic composition comprising a compound having the structure of Compound ID 1004
or a pharmaceutically acceptable salt thereof.
13. A diagnostic composition comprising a compound having the structure of Compound ID 1013
or a pharmaceutically acceptable salt thereof.
14. A diagnostic composition comprising the amino acid sequence:
W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 828);
G-W-H-C-Y-T-Y-F-P-H-H-Y-C-T-Y-G (SEQ. ID NO. 829);
A-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 830);
L-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 831); or
Y-W-H-C-Y-T-Y-F-P-H-H-Y-C-V-Y-G (SEQ. ID NO. 832), or a pharmaceutically acceptable salt thereof.
15. A diagnostic composition comprising a compound having the structure of Compound ID No. 1014
or a pharmaceutically acceptable salt thereof.
16. The diagnostic composition of claim 15 , further comprising a pharmaceutically acceptable ingredient, excipient, carrier, adjuvant, or vehicle.
17. The diagnostic composition of claim 1 , 2 , 3 - 11 , 12 , 13 , or 14 , further comprising a pharmaceutically acceptable ingredient, excipient, carrier, adjuvant, or vehicle.