IP Library Granted Patent US 8,045,679
Granted Patent B2
US 8,045,679 · App. 12/492,216 · Granted Oct 25, 2011

Charged particle cancer therapy X-ray method and apparatus

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Quick Facts
Patent No.
US 8,045,679
App. No.
12/492,216
Granted
Oct 25, 2011
Kind
B2
Abstract

The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Claims (44)

1. An X-ray apparatus as part of a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said apparatus comprising:

an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position: (1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam; and

a synchrotron accelerating the charged particle beam, wherein said synchrotron comprises exactly four, ninety degree, turning sections,

wherein the tumor is targeted using X-ray images collected using X-rays from said X-ray generation source,

wherein the tumor is treated using the charged particle beam, and

wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam.

2. The apparatus of claim 1 , wherein said X-ray generation source comprises a tungsten anode.

3. The apparatus of claim 2 , further comprising:

an electron generating cathode;

a control electrode;

a plurality of accelerating electrodes;

a magnetic lens; and

a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and an X-ray generating anode in said X-ray generation source, said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet combining to form a substantially parallel electron beam with an electron beam cross-sectional area, wherein a cross-sectional area of said cathode is greater than about eight times that of the electron beam cross-sectional area.

4. The apparatus of claim 3 , wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields an X-ray beam comprising a nearly circular cross sectional shape when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam.

5. The apparatus of claim 4 , further comprising a cooling element connected to a backside of said tungsten anode.

6. The apparatus of claim 1 , wherein use of said X-ray generation source occurs within thirty seconds of subsequent use of the charged particle beam for tumor therapy.

7. The apparatus of claim 1 , wherein said synchrotron comprises:

exactly four turning sections; and

no quadrupoles in the circulating path of the synchrotron.

8. An X-ray method as part of a particle beam cancer therapy system, said particle beam cancer therapy system irradiating a tumor of a patient with a charged particle beam during use, said method comprising the steps of:

generating X-rays with an X-ray generation source located within forty millimeters of the charged particle beam, wherein said X-ray source maintains a single static position: (1) during use of said X-ray source and (2) during tumor treatment with the charged particle beam;

accelerating the charged particle beam with a synchrotron, wherein said synchrotron comprises:

exactly four turning sections; and

no quadrupoles in the circulating path of the synchrotron;

targeting the tumor targeted using X-ray images collected using X-rays from said X-ray generation source; and

treating the tumor using the charged particle beam,

wherein the X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam.

9. The method of claim 8 , wherein said X-ray generation source comprises a tungsten anode.

10. The method of claim 9 , further comprising the step of:

generating electrons with a cathode, said cathode having a first cross-sectional distance, wherein the X-rays are generated by the electrons from said cathode striking said tungsten anode.

11. The method of claim 10 , further comprising the steps of:

focusing the electrons from said first cross-sectional distance to a second cross-sectional distance with a focusing control electrode; and

accelerating the electrons with accelerating electrodes, said focusing control electrode and said accelerating electrodes located between said cathode and said anode.

12. The method of claim 10 , further comprising the step of:

forming a substantially parallel electron beam with a control electrode, accelerating electrodes, a magnetic lens, and a quadrupole magnet, all of said control electrode, said accelerating electrodes, said magnetic lens, and said quadrupole magnet located between said cathode and said anode,

wherein the electron beam comprises a cross-sectional area, wherein a cross-sectional area of said cathode is greater than about eight times that of the electron beam cross-sectional area.

13. The method of claim 12 , further comprising the step of:

forming a substantially circular cross-section X-ray beam, wherein said substantially parallel electron beam comprises an oblong cross-sectional shape, wherein geometry of said X-ray generation source yields the substantially circular cross section X-ray when struck by the electron beam having said oblong cross-sectional shape, the X-ray beam running substantially in parallel with the charged particle beam.

14. The method of claim 12 , further comprising the step of:

cooling said tungsten anode with a cooling element connected to a backside of said tungsten anode.

15. The method of claim 8 , further comprising the step of:

using said X-ray generation source within thirty seconds of subsequent use of the charged particle beam for tumor therapy.

16. The method of claim 8 , wherein said synchrotron comprises:

exactly four, ninety degree, turning sections.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2021
From: BALAKIN, VLADIMIR
To: BALAKIN, ANDREY VLADIMIROVICH; BALAKIN, PAVEL VLADIMIROVICH
Reel/Frame 056252/0839 →
SECURITY INTEREST Recorded Jun 27, 2014
From: PROTOM INTERNATIONAL, INC; PROTOM INTERNATIONAL, LLC
To: MICHAELSON CAPITAL SPECIAL FINANCE FUND LP
Reel/Frame 033246/0351 →
RELEASE OF SECURITY INTEREST Recorded Jun 25, 2014
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: PROTOM INTERNATIONAL, INC; PROTOM INTERNATIONAL, LLC; BALAKIN, VLADIMIR
Reel/Frame 033227/0562 →
SECURITY AGREEMENT Recorded Jul 2, 2012
From: PROTOM INTERNATIONAL INC.; PROTOM INTERNATIONAL LLC; BALAKIN, VLADIMIR
To: WILMINGTON TRUST, NATIONAL ASSOCIATION (AS AGENT)
Reel/Frame 028487/0065 →