Bone growth compositions and methods
View Patent ↗The present invention provides an improved technique for spinal fusion involving the administration of an HMG-CoA reductase inhibitor to a fusion. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to the site by a non-compressible delivery vehicle. The invention is suitable for promoting non-anatomic or heterotopic bone growth between any bony surfaces where bone growth is desired but does not naturally occur.
1. A method for promoting arthrodesis, comprising administering an HMG-CoA reductase inhibitor to a malformed or degenerated joint.
2. The method of claim 1 wherein said malformed or degenerated joint is an ankle joint.
3. The method of claim 1 wherein said malformed or degenerated joint is a metatarsophalangeal joint.
4. The method of claim 1 wherein said malformed or degenerated joint is a calcaneal joint.
5. The method of claim 1 wherein said malformed or degenerated joint is a hip joint.
6. The method of claim 1 wherein said malformed or degenerated joint is a facet joint.
7. The method of claim 1 wherein the HMG-CoA reductase inhibitor is lovastatin, pravastatin, simvastatin, atorvastatin, dalvastatin, fluindostatin, cerivastatin, mevastatin, or velostatin.
8. The method of claim 1 wherein the HMG-CoA reductase inhibitor is administered using a carrier.
9. The method of claim 8 wherein the carrier is a non-compressible carrier.
10. The method of claim 9 wherein the carrier comprises steel, ceramic, titanium, coral or hydroxyapatite.
11. The method of claim 9 , wherein the non-compressible carrier is coated with the HMG-CoA reductase inhibitor.
12. The method of claim 8 wherein the carrier is a compressible carrier.
13. The method of claim 12 wherein the compressible carrier is a hydrogel.
14. The method of claim 12 wherein the carrier is an open cell matrix.
15. The method of claim 14 wherein the open cell matrix is formed from collagen fibers.
16. The method of claim 15 wherein the collagen fibers are coated with resorbable hydroxyapatite.
17. The method of claim 16 wherein the hydroxyapatite further comprises calcium.
18. The method of claim 8 wherein the carrier further comprises an antibiotic, an antioxidant, an anti-inflammatory, a growth factor, an immunosuppressant, an analgesic, or a combination thereof.
19. The method of claim 7 wherein the HMG-CoA reductase inhibitor is lovastatin.
20. The method of claim 1 wherein the step of administering the HMG-CoA reductase inhibitor includes the step of applying the HMG-CoA reductase inhibitor with a time release drug delivery system.
21. The method of claim 20 wherein the time release drug delivery system comprises a hydrogel.
22. The method of claim 1 wherein the step of administering the HMG-CoA reductase inhibitor includes administering 0.1-1 gram of the HMG-CoA reductase inhibitor to the site per treatment.
23. The method of claim 22 wherein treatment is repeated 3-5 times.
24. The method of claim 1 wherein said inhibitor is administered directly or locally.
25. The method of claim 1 , wherein said promoting arthrodesis is for failed arthroplasty.