Artificial tear compositions comprising a combination of nonionic surfactants
The invention provides artificial tear compositions comprising one or more nonionic surfactants with one or more non-Newtonian viscosity enhancing excipients.
1. An artificial tear composition comprising:
a non-Newtonian viscosity enhancing excipient selected from the group consisting of 0.10% to 0.75% w/v hydroxypropylmethyl cellulose and 0.20% to 0.80% w/v carboxymethyl cellulose;
and at least the following nonionic surfactants: 5.0% w/v polyoxyl 40 stearate, 0.2% w/v poloxamer 407, and 0.1% w/v poloxamer 188.
2. The composition of claim 1 further comprising 0.25% w/v sodium chloride and 0.01% w/v benzalkonium chloride.
3. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.10% w/v.
4. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.20% w/v.
5. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.30% w/v.
6. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.40% w/v.
7. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.50% w/v.
8. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.62% w/v.
9. The composition of claim 1 wherein, hydroxypropylmethyl cellulose is at an amount of 0.75% w/v.
10. The artificial tear composition of claim 1 further comprising glycerin at an amount from about 0.1% to about 1.0% w/v.
11. An artificial tear composition comprising:
a non-Newtonian viscosity enhancing excipient selected from the group consisting of carboxymethyl cellulose, carboxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, and hydroxypropylmethyl cellulose or a combination thereof;
at least the following nonionic surfactants: 5% w/v polyoxyl 40 stearate, 0.2% w/v poloxamer 407, 0.1% w/v poloxamer 188, from 0.25% to 1.5% w/v polyoxyl 35 castor oil;
0.25% w/v sodium chloride; and
benzalkonium chloride or a perborate.
12. The artificial tear composition of claim 11 , wherein polyoxyl 35 castor oil is 0.25% w/v and the viscosity enhancing excipient is 0.30% w/v hydroxypropylmethyl cellulose.
13. The artificial tear composition of claim 11 , wherein polyoxyl 35 castor oil is 1.00% w/v and the viscosity enhancing excipient is 0.30% w/v hydroxypropylmethyl cellulose.
14. The artificial tear composition of claim 11 , wherein polyoxyl 35 castor oil is 1.50% w/v the viscosity enhancing excipient is 0.30% w/v hydroxypropylmethyl cellulose.
15. A method of treating eye discomfort comprising administering the artificial tear composition of claim 1 to a subject in need thereof.
16. A method of treating eye comprising administering the artificial tear composition of claim 11 to a subject in need thereof.
17. A method of cleaning a contact lens comprising contacting a contact lens with the artificial tear composition of claim 11 .