Tannin formulation for treating gastrointestinal spasms triggered by stress
Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
1. A method of treating a gastrointestinal spasm triggered by stress in a subject, the method comprising:
administering an effective amount of a formulation to a subject having a gastrointestinal spasm triggered by stress, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient;
wherein,
the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and,
the formulation relieves a gastrointestinal spasm triggered by stress in the subject when compared to a second subject in a control group also having a gastrointestinal spasm triggered by stress in which the formulation was not administered.
2. The method of claim 1 , wherein the tannin is a hydrolysable tannin.
3. The method of claim 1 , wherein the tannin is a water soluble condensed tannin.
4. The method of claim 1 , wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin.
5. The method of claim 1 , wherein the tannin is a flavanol.
6. The method of claim 1 , wherein the tannin is a catechin.
7. The method of claim 1 , wherein the tannin is gallic acid, epigallic acid, or a combination thereof.
8. The method of claim 1 , wherein the weight ratio of the tannin:peroxide ranges from about 1:1 to about 1:50.
9. The method of claim 1 , wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue.
10. A method of treating a gastrointestinal spasm triggered by stress in a subject, comprising:
administering an effective amount of a formulation to a subject having a gastrointestinal spasm triggered by stress, the formulation produced from a process including
combining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
removing free hydrogen peroxide from the combination; and,
mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation;
wherein,
the administering includes selecting a desired concentration of the formulation for the administering; and,
the formulation relieves a gastrointestinal spasm triggered by stress in the subject when compared to a second subject in a control group also having a gastrointestinal spasm triggered by stress in which the formulation was not administered.
11. The method of claim 10 , wherein the tannin is a hydrolysable tannin.
12. The method of claim 10 , wherein the tannin is a water soluble condensed tannin.
13. The method of claim 10 , wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin.
14. The method of claim 10 , wherein the tannin is a flavanol.
15. The method of claim 10 , wherein the tannin is a catechin.
16. The method of claim 10 , wherein the tannin is gallic acid, epigallic acid, or a combination thereof.
17. The method of claim 10 , wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue.
18. The method of claim 10 , wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue.
19. The method of claim 1 , wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues.
20. The method of claim 2 , wherein the hydrolysable tannin is a product of a water extraction of Chinese gall.
21. The method of claim 3 , wherein the water soluble condensed tannin is a product of a water extraction of green tea leaves.
22. The method of claim 1 , wherein the tannin is a gallotannin.
23. The method of claim 1 , wherein the tannin is an ellagitannin.
24. The method of claim 23 , wherein the tannin is a punicalagin.
25. A method of treating a gastrointestinal spasm triggered by stress in a subject, comprising:
administering an effective amount of a composition to a subject having a gastrointestinal spasm triggered by stress, the composition produced from a process including
combining a water soluble, hydrolysable tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
wherein,
the administering includes selecting a desired concentration of the formulation for the administering; and,
the formulation relieves a gastrointestinal spasm triggered by stress in the subject when compared to a second subject in a control group also having a gastrointestinal spasm triggered by stress in which the formulation was not administered.
26. The method of claim 25 , wherein the water soluble tannin is a gallotannin or an ellagitannin, and the mixing further comprises removing free hydrogen peroxide from the combination; and, mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation.
27. The method of claim 25 , wherein the tannin is an ellagitannin.
28. The method of claim 27 , wherein the tannin is a punicalagin.