Antibacterial agents

1. A compound of Formula 1 or Formula 2

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is H, cyclic or acyclic alkyl, cyclic or acyclic alkyl-hydroxyamine, aryl, aryl-hydroxyamine, cyclic or acyclic acyl, cyclic or acyclic acyl-hydroxyamine, heteroalkyl, heteroalkyl-hydroxyamine, heteroaryl, heteroaryl-hydroxyamine, acylaryl, acylaryl-hydroxyamine, acylheteroaryl, acylheteroaryl-hydroxyamine, alkylaryl, alkylaryl-hydroxyamine, alkylheteroaryl, alkylheteroaryl-hydroxyamine, sulfonylalkyl, sulfonylalkyl-hydroxyamine, acylalkoxylsulfonylalkyl, or acylalkoxylsulfonylalkyl-hydroxyamine;

or R 1 is C(O)—NR 4 R 5 , where R 4 and R 5 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, urea, and carbamate;

or R 1 is a D-glucose, D-mannose, D-xylose, D-galactose, L-fucose, D-ribose, D-arabinose, D-ribulose, D-fructose, sucrose, lactose, maltose, cellobiose, glucosamine, galactosamine, acetylglucose, acetylgalactose, N-acetylglucosamine, N-acetyl-galactosamine, galactosyl-N-acetylglucosamine, N-acetylneuraminic acid, mycaminose, L-vancosamine, 3-desmethyl-vancosamine, 3-epi-vancosamine, 4-epi-vancosamine, acosamine, 3-amino-glucose, 4-deoxy-3-amino-glucose, actinosamine, daunosamine, 3-epi-daunosamine, ristosamine, or N-methyl-D-glucamine, or clindamycin, each of which is optionally oxidized, reduced, or substituted;

R 2 and R 3 are OH, or R 2 and R 3 are taken together to form a carbonate or carbamate of the formula:

where Z is O, or —N(R 6 ); where R 6 is hydrogen, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, dimethylaminoalkyl, acyl, or sulfonyl, or a group of the formula A-B-T-C, where T is a triazole;

X is H; and Y is OR 7 ; where R 7 is a pentose, hexose, alkyl, aryl, heteroaryl, acyl or —C(O)—NR 8 R 9 , where R 8 and R 9 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, heteroalkyl, aryl, heteroaryl, alkoxy, dimethylaminoalkyl, acyl, sulfonyl, ureyl and carbamyl;

or X and Y are taken together with the attached carbon to form carbonyl;

V is —C(O)—, —C(═NR 11 )—, —C(NR 12 R 13 )—, or —N(R 14 )CH 2 —, wherein the first dash of each of the foregoing V groups is attached to the C-10 carbon and the last dash of each group is attached to the C-8 carbon; and R 11 is hydroxy or alkoxy, R 12 and R 13 are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureyl, and carbamoyl; and R 14 is hydrogen, hydroxy, alkyl, aralkyl, alkylaryl, alkoxy, heteroalkyl, aryl, heteroaryl, dimethylaminoalkyl, acyl, sulfonyl, ureyl or carbamoyl;

W is H, F, Cl, Br, I, or OH;

A is —CH 2 —, —C(O)—, —C(O)O—, —C(O)NH—, —S(O) 2 —, —S(O) 2 NH—, or —C(O)NHS(O) 2 —;

B is —(CH 2 ) n — where n is an integer ranging from 0-10, or B is an unsaturated carbon chain of 2-10 carbons, which may contain any alkenyl or alkynyl group;

C is alkyl, aralkyl, alkylaryl, heteroalkyl, aryl, heteroaryl, aminoaryl, or alkylaminoaryl and

R 10 is hydrogen or acyl.

2. The compound of claim 1 of Formula 1, or a pharmaceutically acceptable salt thereof, wherein R 1 is a D-glucose, D-mannose, D-xylose, D-galactose, L-fucose, D-ribose, D-arabinose, D-ribulose, D-fructose, sucrose, lactose, maltose, cellobiose, glucosamine, galactosamine, acetylglucose, acetylgalactose, N-acetylglucosamine, N-acetyl-galactosamine, galactosyl-N-acetylglucosamine, N-acetylneuraminic acid, mycaminose, L-vancosamine, 3-desmethyl-vancosamine, 3-epi-vancosamine, 4-epi-vancosamine, acosamine, 3-amino-glucose, 4-deoxy-3-amino-glucose, actinosamine, daunosamine, 3-epi-daunosamine, ristosamine, or N-methyl-D-glucamine, or clindamycin, each of which is optionally oxidized, reduced, or substituted.

3. The compound of claim 2 wherein R 1 is mycaminose or 4-deoxy-3-amino-glucose.

4. The compound of claim 2 wherein R 1 is clindamycin.

5. The compound of claim 1 of Formula 1, wherein R 6 is a group of the formula A-B-T-C, where T is a triazole.

6. The compound of claim 1 of Formula 2, or a pharmaceutically acceptable salt thereof.

7. The compound of claim 6 wherein X and Y are taken together with the attached carbon to form carbonyl.

8. The compound of claim 6 wherein V is —C(O)—.

9. The compound of claim 6 wherein W is H or F.

10. The compound of claim 9 wherein W is F.

11. The compound of claim 6 wherein A is —CH 2 —, B is —(CH 2 ) n —, and n is an integer from 2-4.

12. The compound of claim 11 wherein n is 3.

13. The compound of claim 6 wherein C is optionally substituted aryl or optionally substituted heteroaryl.

14. The compound of claim 13 wherein C is 3-aminophenyl.

15. The compound of claim 6 wherein R 10 is hydrogen.

16. A pharmaceutical composition comprising a compound of claim 6 and one or more carriers, diluents, or excipients, or a combination thereof.

17. A unit dosage form comprising a therapeutically effective amount of a compound of claim 6 .

18. A method for treating a disease comprising a bacterial infection in a host animal, the method comprising the step of administering a therapeutically effective amount of a compound of claim 6 to the host animal.

19. The method of claim 18 wherein the bacterial infection is a respiratory tract infection.

20. The method of claim 18 wherein the disease is pneumonia.