IP Library Granted Patent US 9,227,089
Granted Patent B1
US 9,227,089 · App. 12/657,115 · Granted Jan 5, 2016

Skin treatment for promoting hair growth

Inventors: Joseph F. Greco (Sarasota, FL); Robert J. Brandt (Fort Myers, FL)
Assignee: PGFX PATENT HOLDINGS, LLC
A61Q7/00A61K35/19
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,227,089
App. No.
12/657,115
Granted
Jan 5, 2016
Kind
B1
Abstract

A volume of platelet-rich blood product is obtained from a volume of anti-coagulated blood to prepare a composition for promoting the growth of hair follicles within skin. A portion of the skin is traumatized to form a treatment area in which stem cells within the hair follicles are activated. A protein matrix is formed from the platelet-rich blood product composition to entrap growth factors. The platelet-rich blood product composition is infused into the treatment area to form a complex between the protein matrix and the growth factors so that the stem cells attach to the complex and proliferate within the hair follicles.

Claims (26)

1. A method for promoting hair growth within skin that includes a plurality of hair follicles comprising:

obtaining a volume of a platelet-rich blood product composition from a volume of anti-coagulated blood to include a natural protein extra cellular matrix containing growth factors,

traumatizing a portion of the bald area of scalp of a human patient containing hair follicles within a treatment area of the scalp to activate stem cells within the hair follicles to form a quantity of activated stem cells within the treatment area, and

infusing the natural protein extra cellular matrix containing growth factors into the treatment area to interact with the activated stem cells to form a complex between the protein extra cellular matrix of growth factors and the activated stem cells so that the activated stem cells proliferate within the treatment area to grow new hair follicles.

2. A method as set forth in claim 1 wherein the traumatizing further includes:

traumatizing a portion of the scalp with a trauma instrument selected from the group consisting of a mechanical incision trauma instrument, a micro needling roller, a laser, a light source, a photo therapy instrument, an ultrasonic instrument, an electroportation instrument, an epidermal abrasion instrument, a dermal abrasion instrument, a heater, a cooler, a chemical dispenser, a liquid dispenser, a gel dispenser, a lotion dispenser, a cream dispenser, a gas dispenser, a vapor dispenser, and a naturopathic chemical dispenser.

3. A method as set forth in claim 1 wherein the infusing further includes:

infusing the natural protein extra cellular matrix containing growth factors concentrated protein matrix into the treatment area through a technique selected from the group consisting of injection, micro needling, ultrasound, electroportation, transdermal infusion, patching, dressing, vacuum assisted infusion, mechanical infusion, chemical infusion, and mineral infusion.

4. A method as set forth in claim 1 wherein the obtaining further includes:

separating a volume of platelet-rich plasma from the volume of anti-coagulated blood,

forming the platelet-rich blood product composition with a preselected volume of platelet-rich plasma

separating a volume of concentrated platelet poor plasma from the volume of anti-coagulated blood, and

mixing the volume of concentrated platelet poor plasma with the platelet-rich plasma to form the platelet-rich blood product composition.

5. A method as set forth in claim 1 wherein the obtaining further includes:

placing a volume of anticoagulated blood into a centrifuge machine and centrifugally separating the volume of blood, at a first speed, into a platelet poor plasma component, a buffy coat component, and a layer of red blood cells, the buffy coat component comprising platelets,

transferring the platelet poor plasma component from the volume of blood to a first collection device,

extracting additional platelets from the red blood cell layer into the buffy coat component to form a concentrated platelet-rich plasma component,

hemoconcentrating the concentration of platelets within the platelet poor plasma component to produce a concentrated platelet-poor plasma component, and

combining the concentrated platelet-poor plasma component with the concentrated platelet-rich plasma component to form the platelet-rich blood product composition.

6. A method as set forth in claim 1 wherein the infusion further includes:

combining the natural protein extra cellular matrix with implantable cells selected from the group consisting of implantable hair cells, implantable stem cells, and both implantable hair cells and implantable stem cells to form a mixture of the platelet-rich blood product composition and the implantable cells, and

applying the mixture to the treatment area to infuse the natural protein extra cellular matrix with implantable cells into the treatment area.

7. A method as set forth in claim 1 wherein the traumatizing and infusing further include:

providing an elongated member having a container for holding the platelet-rich blood product composition at one end and a roller with a plurality of protrusions for traumatizing the treatment area of the scalp extending from the opposite end,

rotating the roller on the treatment area to traumatize the treatment area, and

dispensing the platelet-rich blood product composition from the container to infuse the platelet-rich blood product composition into the treatment area.

Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2014
From: OROGEN BIOSCIENCES, INC.
To: PGFX PATENT HOLDINGS, LLC
Reel/Frame 033297/0240 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2013
From: OROGEN HOLDINGS, INC.
To: OROGEN BIOSCIENCES, INC.
Reel/Frame 030724/0408 →
SECURITY AGREEMENT Recorded Nov 26, 2012
From: OROGEN BIOSCIENCES, INC.
To: GALEN, CLARK; BRANDT, ROBERT J.; BRANDT, RYAN N.; GRECO, JOSEPH; KIWCZAK, JOHN; NELSON, GARY H.
Reel/Frame 029406/0630 →
SECURITY INTEREST Recorded Nov 14, 2012
From: OROGEN BIOSCIENCES, INC.
To: GALEN, CLARK; BRANDT, ROBERT J.; BRANDT, RYAN N.; GRECO, JOSEPH; KIWCZAK, JOHN; NELSON, GARY H.
Reel/Frame 029361/0202 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE ASSIGNEE, PREVIOUSLY RECORDED ON REEL 25782 FRAME 0995. Recorded Feb 28, 2011
From: OROGEN BIOSCIENCES, INC
To: OROGEN HOLDINGS, LLC
Reel/Frame 025965/0048 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 11, 2011
From: OROGEN BIOSCIENCES INC.
To: OROGEN HOLDINGS, INC
Reel/Frame 025782/0995 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 5, 2010
From: GRECO, JOSEPH F.; BRANDT, ROBERT J.
To: OROGEN BIOSCIENCES, INC.
Reel/Frame 024193/0541 →
Continuity (1)
Provisional Application 61205045 · Jan 14, 2009