Bioactive composites of polymer and glass and method for making same
View Patent ↗The present invention relates to a method of preparing a bioactive composite, the method comprising the steps of a) adding in a solid state a biocompatible polymer and a bioactive glass to an extruder to form an extrudable material; b) applying energy to the extrudable material to at least the melting temperature of the biocompatible polymer to melt mix the biocompatible polymer and bioactive glass; and c) extruding a bioactive composite.
1. A method of preparing a bioactive composite, comprising:
a) heating polyaryletherketone polymer particles to at least the melting temperature of the polyaryletherketone polymer to at least partially melt the polyaryletherketone polymer particles, wherein the polyaryetherketone polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the polyaryletherketone polymer has a molecular weight ranging from 70,000 to 120,000 Daltons prior to heating;
b) adding alkali-containing bioactive glass particles to the at least partially melted polyaryletherketone particles,
wherein the alkali-containing bioactive glass particles have a particle size ranging from 1 μm to 500 μm; and
c) extruding a bioactive composite, wherein the polyaryletherketone polymer is present in an amount of 70% to 85% by weight of the extruded bioactive composite, and wherein the alkali-containing bioactive glass particles is present in an amount of 15% to 30% by weight of the extruded bioactive composite.
2. The method of claim 1 , wherein prior to adding the alkali-containing bioactive glass particles, further comprising:
mixing the at least partially melted polyaryletherketone polymer particles.
3. The method of claim 1 , wherein the polyaryletherketone polymer is polyetheretherketone (PEEK).
4. The method of claim 3 , wherein the PEEK polymer is present in an amount of 70% to 80% by weight of the extruded bioactive composite, and wherein the alkali-containing bioactive glass particles is present in an amount of 20% to 30% by weight of the extruded bioactive composite.
5. The method of claim 1 , wherein the alkali-containing bioactive glass particles are 45S5 or Combeite glass-ceramic.
6. The method of claim 1 , wherein the alkali-containing bioactive glass particles have a particle size range from 50 μm to 250 μm.
7. The method of claim 1 , wherein the composite is non-resorbable.
8. The method of claim 1 , wherein the amount by weight of the alkali-containing bioactive glass particles in the extruded bioactive composite, measured in a plurality of samples taken from the composite, has a standard deviation ranging from 0.10 to 0.33.
9. A method of preparing a homogeneous bioactive shaped body, comprising:
a) heating polyaryletherketone polymer particles to at least the melting temperature of the polyaryletherketone polymer to at least partially melt the polyaryletherketone polymer particles, wherein the polyaryetherketone polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the polyaryletherketone polymer has a molecular weight ranging from 70,000 to 120,000 Daltons prior to heating;
b) adding alkali-containing bioactive glass particles to the at least partially melted polyaryletherketone polymer particles, wherein the alkali-containing bioactive glass particles have a particle size ranging from 1 μm to 500 μm; and
c) extruding homogeneous pellets of polyaryletherketone polymer and alkali-containing bioactive glass particles, wherein the polyaryletherketone polymer is present in an amount of 70% to 80% by weight of the homogeneous pellets, and wherein the alkali-containing bioactive glass particles are present in an amount of 20% to 30% by weight of the homogeneous pellets; and
d) injection molding the homogeneous pellets to form the homogeneous bioactive shaped body.
10. The method of claim 9 , wherein prior to adding the alkali-containing bioactive glass particles, further comprising:
mixing the at least partially melted polyaryletherketone polymer particles.
11. The method of claim 9 , wherein the polyaryletherketone polymer is polyetheretherketone (PEEK).
12. The method of claim 11 , wherein the alkali-containing bioactive glass particles has a particle size range from 50 μm to 250 μm.
13. The method of claim 9 , wherein the alkali-containing bioactive glass particles are 45S5 or Combeite glass-ceramic.
14. The method of claim 9 , wherein the composite is non-resorbable.
15. A method of preparing a bioactive composite, comprising:
a) heating polyetheretherketone (PEEK) polymer particles to at least the melting temperature of the PEEK polymer to at least partially melt the PEEK polymer particles, wherein the PEEK polymer particles have a particle size ranging from 1,000 μm to 4,000 μm prior to heating, and wherein the PEEK polymer has a molecular weight ranging from 100,000 to 120,000 Daltons prior to heating;
b) adding alkali-containing bioactive glass particles to the at least partially melted PEEK polymer particles, wherein the bioactive glass particles have a particle size range from 1 μm to 500 μm; and
c) extruding a bioactive composite, wherein the PEEK polymer is present in an amount of 70% to 80% by weight of the extruded bioactive composite, and wherein the alkali-containing bioactive glass particles is present in an amount of 20% to 30% by weight of the extruded bioactive composite.
16. The method of claim 15 , wherein prior to adding the alkali-containing bioactive glass particles, further comprising:
mixing the at least partially melted PEEK polymer particles.
17. The method of claim 1 , wherein the bioactive composite is dry mixed.
18. The method of claim 9 , wherein the shaped body is prepared without the use of water or a solvent.
19. The method of claim 15 , wherein the bioactive composite is dry mixed.