Ophthalmic drug delivery
View Patent ↗The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
1. A method for delivering a reduced volume of ophthalmic solution to the eye comprising:
(a) generating an ejected stream of droplets of an ophthalmic solution via a piezoelectric actuated ejection device, the ejection device comprising: a housing; a reservoir disposed within the housing for receiving a volume of ophthalmic solution; an ejector mechanism comprising an ejector plate coupled to a fluid delivery area of the reservoir, the ejector plate including a plurality of openings formed through its thickness; and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to thereby generate the ejected stream of droplets upon actuation, wherein said droplets have an average ejecting droplet size of between about 20 microns and about 100 microns in diameter and an average initial ejecting velocity of between about 1 m/s and 10 m/s; and
(b) delivering said ejected stream of droplets of the ophthalmic solution to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye and wherein said deposited droplets provide a total volume of less than 30 μl to said eye.
2. The method of claim 1 , wherein said ophthalmic solution is an isotonic saline solution.
3. The method according to claim 1 , wherein said ophthalmic solution comprises a medicament and said medicament is delivered in an aqueous droplet solution.
4. The method according to claim 1 , wherein said ophthalmic solution comprises a medicament and said medicament is delivered in an oil/water emulsion droplet.
5. The method according to claim 4 , wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
6. The method according to claim 3 , wherein said medicament is a glaucoma medicament.
7. The method according to claim 3 , wherein said medicament is an antibiotic.
8. The method according to claim 1 , wherein said average droplet ejecting size is between about 30 microns to about 60 microns in diameter.
9. The method according to claim 1 , wherein said average droplet initial ejecting velocity is between about 1 m/s to about 5 m/s.
10. The method according to claim 1 , wherein said deposited droplets provide a total volume of less than 10 μl to said eye.
11. The method according to claim 3 , wherein said medicament comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HCl, pheniramine maleate, ketotifen fumarate, oxymetazoline HCl, naphazoline HCl, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost.
12. The method according to claim 3 , wherein said medicament comprises a medicament selected from the group consisting of sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HCl, propylene glycol, zinc sulfate, dorzolamide HCl-timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HCl, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine.
13. The method according to claim 3 , wherein said medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl-timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK free latanoprost.
14. A method of treating glaucoma in a subject in need thereof with a reduced volume of a glaucoma medicament, the method comprising:
(a) generating an ejected stream of droplets containing said glaucoma medicament via a piezoelectric actuated ejection device, the ejection device comprising: a housing; a reservoir disposed within the housing for receiving a volume of ophthalmic solution; an ejector mechanism comprising an ejector plate coupled to a fluid delivery area of the reservoir, the ejector plate including a plurality of openings formed through its thickness; and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to thereby generate the ejected stream of droplets upon actuation, wherein said droplets have an average droplet size of between about 20 microns and about 100 microns in diameter and an average initial ejecting velocity of between about 1 m/s and 10 m/s; and
(b) delivering said ejected stream of droplets containing said glaucoma medicament to the eye of said subject in need thereof, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye and wherein said deposited droplets provide a total volume of less than 30 μl to said eye.
15. The method according to claim 14 , wherein said glaucoma medicament is delivered in an aqueous droplet solution.
16. The method according to claim 15 , wherein said glaucoma medicament is delivered in an oil/water emulsion droplet.
17. The method according to claim 16 , wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
18. The method according to claim 14 , wherein said average droplets ejecting size is between about 30 microns to about 60 microns in diameter.
19. The method according to claim 14 , wherein said average droplet initial ejecting velocity is between about 1 m/s to about 5 m/s.
20. The method according to claim 14 , said glaucoma medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK free latanoprost.