IP Library › Granted Patent US 10,364,211
Granted Patent B1
US 10,364,211 · App. 16/169,056 · Granted Jul 30, 2019

Methods and intermediates for synthesizing SK1-I

Inventors: Zaiguo Li (Little Neck, NY); Natarajan Raju (Germantown, MD); Praveen Pande (Holbrook, NY)
Assignee: Enzo Biochem, Inc.
C07C215/28C07C213/08C07D263/06
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Quick Facts
Patent No.
US 10,364,211
App. No.
16/169,056
Granted
Jul 30, 2019
Kind
B1
Abstract

The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4′-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.

Claims (4)

1. A method for synthesizing the compound

comprising the reaction steps of:

(vii) reacting

with DIBAL in the presence of Rochelle salt, thereby obtaining

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2026
From: ENZO BIOCHEM, INC.; ENZO LIFE SCIENCES, INC.; ENZO THERAPEUTICS, INC.
To: SERAPH BIOTECH CONSULTING, LLC
Reel/Frame 075219/0465 →
RELEASE OF SECURITY INTEREST Recorded Jul 24, 2023
From: GEMINO HEALTHCARE FINANCE, LLC D/B/A SLR HEALTHCARE ABL
To: ENZO BIOCHEM, INC.; ENZO CLINICAL LABS, INC.; ENZO LIFE SCIENCES U.S. HOLDING CORP; ENZO LIFE SCIENCES, INC.
Reel/Frame 064369/0031 →
SECURITY INTEREST Recorded Apr 3, 2023
From: ENZO LIFE SCIENCES, INC.; ENZO CLINICAL LABS, INC.; ENZO BIOCHEM, INC.; ENZO LIFE SCIENCES U.S. HOLDING CORP
To: GEMINO HEALTHCARE FINANCE, LLC D/B/A SLR HEALTHCARE ABL
Reel/Frame 063239/0103 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 14, 2019
From: LI, ZAIGUO; RAJU, NATARAJAN; PANDE, PRAVEEN
To: ENZO BIOCHEM, INC.
Reel/Frame 048330/0267 →
Continuity (1)
Provisional Application 62576943 · Oct 25, 2017