IP Library › Granted Patent US 10,695,433
Granted Patent B2
US 10,695,433 · App. 14/434,821 · Granted Jun 30, 2020

Pyrrolobenzodiazepine-antibody conjugates

Inventors: Patricius Hendrikus Cornelis Van Berkel (Lausanne, CH); Philip Wilson Howard (London, GB)
Assignee: MEDIMMUNE LIMITED
A61K47/48569A61K31/5517A61K47/6803A61K47/6849A61K47/6851
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Quick Facts
Patent No.
US 10,695,433
App. No.
14/434,821
Granted
Jun 30, 2020
Kind
B2
Abstract

Conjugates of an antibody that binds to CD25 with PBD dimers.

Claims (9)

1. A conjugate of formula ConjE:

wherein AB is an antibody that binds to CD25 and comprises a VH domain having the amino acid sequence according to SEQ ID NO:1 paired with a VL domain comprising the amino acid sequence of SEQ ID NO:2; and wherein the drug loading of drugs (D) to antibody (AB) is an integer from 1 to about 8.

2. The conjugate according to claim 1 , wherein the antibody is an intact antibody.

3. The conjugate according to claim 1 , wherein the antibody is humanized, deimmunized, or resurfaced.

4. The conjugate according to claim 1 , wherein the drug loading of drugs (D) to antibody is 1, 2, 3, or 4.

5. A pharmaceutical composition comprising the conjugate of claim 1 and a pharmaceutically acceptable diluent, carrier, or excipient.

6. The pharmaceutical composition of claim 5 , further comprising a therapeutically effective amount of a chemotherapeutic agent.

7. A method of treating cancer comprising administering to a patient the pharmaceutical composition of claim 5 .

8. The method of claim 7 wherein the patient is administered a chemotherapeutic agent, in combination with the conjugate.

Assignments (7)
PATENT SECURITY AGREEMENT Recorded Dec 27, 2022
From: ADC THERAPEUTICS SA
To: OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P.
Reel/Frame 062228/0763 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2019
From: ADC THERAPEUTICS SA
To: MEDIMMUNE LIMITED
Reel/Frame 050339/0591 →
CHANGE OF NAME Recorded Jan 31, 2018
From: ADC THERAPEUTICS SÀRL
To: ADC THERAPEUTICS S.A.
Reel/Frame 046119/0491 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY ADDRESS PREVIOUSLY RECORDED AT REEL: 039791 FRAME: 0157. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 22, 2016
From: HOWARD, PHILIP WILSON
To: MEDIMMUNE LIMITED
Reel/Frame 040107/0618 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: VAN BERKEL, PATRICIUS HENDRIKUS CORNELIS
To: A.T. DEVELOPMENT SWITZERLAND SÀRL
Reel/Frame 039790/0855 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: A.T. DEVELOPMENT SWITZERLAND SÀRL
To: ADC THERAPEUTICS S.A.
Reel/Frame 039790/0982 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: HOWARD, PHILIP WILSON
To: MEDIMMUNE LIMITED
Reel/Frame 039791/0157 →