IP Library Granted Patent US 10,772,321
Granted Patent B2
US 10,772,321 · App. 16/167,615 · Granted Sep 15, 2020

Method for treating blood, blood products and organs

Inventor: Dieter Willbold (Juelich, DE)
Assignee: FORSCHUNGSZENTRUM JUELICH GMBH
A01N1/0278A01N1/0226C07K7/06C07K7/08C07K14/4711A61K38/00G01N2333/4709H05K999/99
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Quick Facts
Patent No.
US 10,772,321
App. No.
16/167,615
Granted
Sep 15, 2020
Kind
B2
Abstract

The invention relates to the treatment of blood, blood products and organs for the removal and/or detoxification of amyloid-beta oligomers.

Claims (21)

1. A method for treating blood, a blood product and/or an organ in vitro or ex vivo, wherein the method comprises removing the blood, blood product and/or organ from the human or animal body and removing and/or detoxifying amyloid-beta oligomers from the removed blood, blood product and/or organ, and wherein the method comprises contacting the blood, blood product and/or organ with the peptide of formula rprtrlhthrnrrprtrlhthrnr (D3D3, SEQ ID NO:13).

2. The method of claim 1 , wherein the method further comprises examining the blood, blood product and/or organ for the presence of amyloid-beta oligomers prior to removing the blood, blood product and/or organ from the human or animal body.

3. The method of claim 1 , wherein molecules of the peptide of SEQ ID NO:13 are arranged as capture molecules on a support, via which a sample containing the blood, blood product and/or organ is passed.

4. The method of claim 3 , wherein the capture molecules are fixed onto beads.

5. The method of claim 3 , wherein the capture molecules are immobilized on nanomagnets.

6. The method of claim 3 , wherein the capture molecules are arranged in a dialysis system.

7. The method of claim 3 , wherein the support for the capture molecules is made of a biocompatible material.

8. The method of claim 3 , wherein the support for the capture molecules is selected from one or more of membranes, filters, filter sponges, beads, rods, cords, column, and hollow fibers.

9. The method of claim 1 , wherein a kit is used for a selective quantification of amyloid-beta aggregates and/or for treating (in vitro) blood, a blood product and/or an organ, the kit comprising one or more of:

a substrate made of glass which is coated with a hydrophobic material;

a standard;

a capture molecule;

a probe;

a substrate with capture molecule;

one or more solutions; and

a buffer.

10. The method of claim 1 , wherein molecules of the peptide of SEQ ID NO:13 are passed as capture molecules ex vivo over and/or through an organ.

11. The method of claim 1 , wherein the method comprises removing amyloid-beta oligomers from blood, a blood product and/or an organ.

12. The method of claim 11 , wherein Alzheimer's disease is treated.

13. The method of claim 1 , wherein the method comprises detoxifying amyloid-beta oligomers present in blood, a blood product and/or an organ.

14. The method of claim 13 , wherein Alzheimer's disease is treated.

Assignments (1)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE APPLICATION NUMBERS PREVIOUSLY RECORDED AT REEL: 058475 FRAME: 0768. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 11, 2022
From: FORSCHUNGSZENTRUM JÜLICH GMBH
To: PRIAVOID GMBH
Reel/Frame 059034/0548 →