Preparation method of dual layered coatings on magnesium alloys with fluorine/polycaprolactone for biomedical applications
The present invention relates to a method for preparing a dual-layer magnesium alloy with fluoride and biopolymer coatings, wherein the dual-layer MgF 2 /PCL coating exhibits improved corrosion resistance as compared to fluoride-coated samples or uncoated Mg samples, and has excellent cell viability, cell adhesion and cell proliferation. Accordingly, the magnesium alloy provided with the dual MgF 2 /PCL coating layer controls corrosion degradation of conventional orthopedic Mg alloys and exhibits excellent biocompatibility, thus being useful as an implant for fixing bones.
1. A method for preparing a dual-layer coating on magnesium alloy comprising:
polishing a surface of a magnesium alloy;
treating the polished magnesium alloy with fluoride to prepare a magnesium fluoride coating layer on the magnesium alloy; and
coating the fluoride coating layer with a biopolymer solution to form a biopolymer layer.
2. The method according to claim 1 , wherein the magnesium alloy comprises zinc, zirconium and magnesium.
3. The method according to claim 1 , wherein the fluoride is hydrofluoric acid.
4. The method according to claim 1 , wherein the polymer is selected from the group consisting of polyetherimide (PEI), polycaprolactone (PCL), chitosan, polylactic acid (PLA), polyglycolic acid (PGA), a poly-ε-caprolactone-lactic acid copolymer (PCLA), a poly-ε-caprolactone-glycolic acid copolymer (PCGA), a polylactic acid-glycolic acid copolymer (PLGA), polyethylene glycol (PEG), polydioxanone (PDO), polytrimethylene carbonate (PTMC), polyamino acid, polyanhydride, polyorthoester, polyphosphazene, polyiminocarbonate, polyphosphoester, polyhydroxyvalerate, a copolymer thereof and a mixture thereof.
5. The method according to claim 1 , wherein the biopolymer solution is prepared by dissolving a biopolymer in dichloromethane.
6. The method according to claim 1 , wherein the fluoride coating layer has a thickness of 1.2 to 3.2 μm.
7. The method according to claim 1 , wherein the biopolymer coating layer has a thickness of 2.0 to 4.3 μm.