Systems and methods for inducing negative pressure in a portion of a urinary tract of a patient
Ureteral or bladder catheters are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion that includes one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon application of negative pressure through the catheter. Systems, kits and methods for inducing negative pressure to increase renal function also are provided.
1. A system for inducing negative pressure in a portion of a urinary tract, the system comprising:
(a) at least one ureteral catheter, the at least one ureteral catheter comprising a distal portion configured for insertion within the kidney, renal pelvis, and/or ureter and a proximal portion; and
(b) a bladder catheter comprising a distal portion comprising a retention portion configured to retain the distal portion within the bladder and a proximal portion configured to transmit negative pressure into the bladder and/or the ureteral catheter, which in turn causes fluid from the kidney to be drawn into and through the ureteral catheter to the bladder catheter, then through the bladder catheter, and then outside of the body.
2. The system according to claim 1 , wherein the distal portion of the ureteral catheter comprises a retention portion that comprises one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon the application of negative pressure.
3. The system according to claim 2 , wherein the one or more protected drainage holes, ports or perforations are disposed on a protected surface area or inner surface area of the retention portion of the ureteral catheter, and wherein, upon application of negative pressure, the mucosal tissue conforms or collapses onto the outer periphery or protective surface area of the retention portion of the ureteral catheter and is thereby prevented or inhibited from occluding the one or more of the protected drainage holes, ports or perforations.
4. The system according to claim 1 , wherein the proximal portion of the ureteral catheter is in fluid communication with the distal portion of the bladder catheter.
5. The system according to claim 1 , wherein the distal portion of the bladder catheter comprises a retention portion that comprises one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon the application of negative pressure.
6. The system according to claim 5 , wherein the one or more protected drainage holes, ports or perforations are disposed on a protected surface area or inner surface area of the retention portion of the bladder catheter, and wherein, upon application of negative pressure, the mucosal tissue conforms or collapses onto the outer periphery or protective surface area of the retention portion of the bladder catheter and is thereby prevented or inhibited from occluding the one or more of the protected drainage holes, ports or perforations.
7. The system according to claim 1 , wherein the system further comprises a negative pressure source for application of negative pressure through both the bladder catheter and the ureteral catheter(s), which in turn causes fluid from the kidney to be drawn into and through the ureteral catheter(s), then through the bladder catheter, and then outside of the body.
8. The system according to claim 7 , wherein the negative pressure source comprises a vacuum source external to the body for application and regulation of negative pressure through both the bladder catheter and the ureteral catheter, which in turn causes fluid from the kidney to be drawn into and through the ureteral catheter, then through the bladder catheter, and then outside of the body.
9. The system according to claim 7 , wherein the negative pressure received from the negative pressure source is controlled manually, automatically, or combinations thereof.
10. The system according to claim 7 , wherein a controller is used to regulate negative pressure from the negative pressure source.
11. The system according to claim 10 , wherein the controller provides an accuracy of about 10 mmHg or less.
12. The system according to claim 7 , wherein the negative pressure is provided within a range of about 2 mm Hg to about 150 mm Hg.
13. The system according to claim 1 , further comprising one or more physiological sensors configured to detect at least one physical parameter.
14. The system according to claim 13 , wherein the at least one physical parameter comprises one or more of volume of urine collected, urine composition, urine protein concentration, blood composition or blood flow.
15. The system according to claim 14 , wherein the at least one physical parameter of blood composition comprises one or more of hematocrit ratio, analyte concentration, protein concentration, or creatinine concentration.
16. The system according to claim 14 , wherein the at least one physical parameter of blood flow comprises one or more of blood pressure or blood flow velocity.
17. The system according to claim 13 , wherein the one or more physiological sensors comprise one or more of pulse oximetry sensor(s), blood pressure sensor(s), heart rate sensor(s), respiration sensor(s), capnography sensor(s), glucose sensor(s), blood velocity sensor(s), hemoglobin sensor(s), hematocrit sensor(s), protein sensor(s), creatinine sensor(s), analyte sensor(s), capacitance sensor(s), optical spectroscopy sensor(s) or combinations thereof.
18. The system of claim 1 , wherein the distal portion of the ureteral catheter is configured to be positioned in a kidney, renal pelvis, and/or ureter of a patient.
19. The system of claim 18 , wherein the patient is an animal.
20. The system of claim 18 , wherein the patient is a human.
21. A kit comprising:
(a) at least one ureteral catheter, the at least one ureteral catheter comprising a distal portion configured for insertion within the kidney, renal pelvis and/or ureter and a proximal portion; and
(b) at least one disposable bladder catheter comprising a distal portion comprising a retention portion configured to retain the distal portion within the bladder and a proximal portion configured to transmit negative pressure into the bladder and/or the ureteral catheter, which in turn causes fluid from the kidney to be drawn into and through the ureteral catheter to the bladder catheter, then through the bladder catheter, and then outside of the body;
instructions for at least one of the following: inserting/deploying the ureteral catheter(s), inserting/deploying the bladder catheter(s) or instructions for connecting a proximal end of the bladder catheter to a pump and for operating the pump to draw urine through the drainage lumen of the bladder catheter.