Invention of non-homologous peptide sequences to interact with amyloid beta and its precursor protein APP by using computer modeling
View Patent ↗The invented non-homologous peptide sequences are able to form dimers with corresponding amyloid beta (Aβ), its precursor protein (APP) and enzyme gamma secretase (GSA) as observed by using fixed z-axis overlay computer modeling. [The dipole moment values of these dimeric peptide structures are increased with respect to individual Aβ peptide (1-42) and APP fragments].
1. The heterodimeric structures are formed between each non-homologous peptide sequence and its corresponding Amyloid beta fragment as follows: [SEQ ID 1] and [SEQ ID 6], [SEQ ID 2] and [SEQ ID 7], [SEQ ID 3] and [SEQ ID 8], [SEQ ID 4] and [SEQ ID 9], and [SEQ ID 5] and [SEQ ID 10].
2. Non-homologous peptide sequences [SEQ ID numbers: 11, 12, 13] construct heterodimeric structures with their corresponding amyloid beta precursor protein (APP) fragments, resulting in the following pairs: [SEQ ID 11] and [SEQ ID 14], [SEQ ID 12] and [SEQ ID 15], [SEQ ID 13] and [SEQ ID 16].
3. All of the amyloid beta precursor proteins (APP) [SEQ ID 14], [SEQ ID 15], and [SEQ ID 16] can bind and form heterodimers with the peptide sequences of Presenilin-1 sequence-b [SEQ 17], Presenilin-1 sequence-c [SEQ 18], and Nicastrin sequence-a1: [SEQ 19].