IP Library Granted Patent US 12,374,438
Granted Patent B1
US 12,374,438 · App. 18/809,611 · Granted Jul 29, 2025

Apparatus and methods for prediction of repeat ablation efficacy

Inventors: Suthirth Vaidya (Bengaluru, IN); Rakesh Barve (Bengaluru, IN); Animesh Agarwal (San Mateo, CA); Samir Awasthi (Boston, MA); Murali Aravamudan (Andover, MA); Maulik Nanavaty (Cambridge, MA)
Assignee: Anumana, Inc.
G16H20/40A61B5/346A61B5/364A61B5/7246A61B5/742A61B18/1492A61B34/10G16H10/60G16H50/70A61B2018/00577A61B2034/104
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,374,438
App. No.
18/809,611
Granted
Jul 29, 2025
Kind
B1
Abstract

An apparatus and method for prediction of pulmonary vein reconnection is disclosed. The apparatus includes an electrocardiogram device, at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to generate ablation evaluation training data, train an ablation evaluation machine-learning model using the ablation evaluation training data, receive, from the electrocardiogram device, the electrocardiogram data, and generate, using the ablation evaluation machine-learning model, ablation evaluation data of the patient, wherein generating the ablation evaluation data of the patient includes inputting, into the ablation evaluation machine-learning model, the electrocardiogram data and receiving as output, from the ablation evaluation machine-learning model, the ablation evaluation data of the patient.

Claims (60)

1. An apparatus for prediction of repeat ablation efficacy, the apparatus comprising:

an electrocardiogram device, wherein the electrocardiogram device is configured to detect post-ablation arrhythmic electrocardiogram (ECG) data representative of a post-ablation arrhythmia of a patient who has previously undergone an ablation procedure at a primary ablation target;

at least a processor; and

a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to:

receive, from the electrocardiogram device, the post-ablation arrhythmic ECG data;

generate, using a repeat-ablation efficacy machine-learning model, repeat-ablation efficacy data representing predicted efficacy of a repeat ablation procedure to resolve an arrhythmia of the patient, wherein generating the repeat-ablation efficacy data of the patient comprises:

iteratively training the repeat-ablation efficacy machine-learning model using training data, wherein ablation evaluation machine-learning model is trained and retrained until it surpasses an accuracy threshold, wherein new patient data is periodically integrated into the training data;

inputting, into the repeat-ablation efficacy machine-learning model, the post-ablation arrhythmic ECG data; and

receiving as output, from the repeat-ablation efficacy machine-learning model, the repeat-ablation efficacy data;

generate, using a treatment machine-learning model, a treatment recommendation based on the repeat-ablation efficacy data, the treatment recommendation comprising performing a repeat ablation procedure at a secondary ablation target on the patient; and

transmit, for display, the repeat-ablation efficacy data; and

an ablation device configured to perform the repeat ablation procedure at the secondary ablation target on the patient according to the generated treatment recommendation to increase a likelihood of success of the repeat ablation procedure.

2. The apparatus of claim 1 , wherein the repeat-ablation efficacy data comprises a predicted chance of pulmonary vein reconnection.

3. The apparatus of claim 1 , wherein generating the ablation training data from the subset of patient health records comprises de-identifying the subset of patient health records.

4. The apparatus of claim 1 , wherein the repeat-ablation efficacy data comprises a quantitative value or a classification.

5. The apparatus of claim 1 , wherein determining the treatment recommendation comprises generating, using the treatment machine-learning model, the treatment recommendation as a function of the post-ablation arrhythmic ECG electrocardiogram-data.

6. The apparatus of claim 5 , wherein determining a treatment recommendation comprises:

receiving treatment training data, wherein the treatment training data comprises historical ECG data correlated to historical treatment data;

training the treatment machine-learning model using the treatment training data; and

generating the treatment recommendation using the trained treatment machine-learning model.

7. The apparatus of claim 5 , wherein:

the apparatus further comprises a display device; and

the memory contains instructions further configuring the at least a processor to display the treatment recommendation using the display device.

8. The apparatus of claim 5 , wherein the memory contains instructions further configuring the at least a processor to:

receive a post-recommended treatment ECG and recommended treatment outcome data; and

retrain the treatment machine-learning model as a function of the post-recommended treatment ECG and the recommended treatment outcome data.

9. The apparatus of claim 1 , wherein:

the memory further comprises instructions configuring the at least a processor to receive prior-procedure intracardiac echocardiogram data; and

generating the repeat-ablation efficacy data of the patient further comprises inputting, into the repeat-ablation efficacy machine-learning model, the prior-procedure intracardiac echocardiogram data.

10. The apparatus of claim 1 , wherein:

the memory further comprises instructions configuring the at least a processor to receive prior-procedure ablation parameter data; and

generating the repeat-ablation efficacy data of the patient further comprises inputting, into the repeat-ablation efficacy machine-learning model, the prior-procedure ablation parameter data.

11. A method for prediction of repeat ablation efficacy, the method comprising:

detecting, using an electrocardiogram device, post-ablation arrhythmic electrocardiogram (ECG) data representative of a post-ablation arrhythmia of a patient who has previously undergone an ablation procedure at a primary ablation target;

receiving, by at least a processor, from the electrocardiogram device, the post-ablation arrhythmia ECG data;

generating, by the at least a processor and using a repeat-ablation efficacy machine-learning model, repeat-ablation efficacy data representing predicted efficacy of a repeat ablation procedure to resolve an arrhythmia of the patient, wherein generating the repeat-ablation efficacy data of the patient comprises:

iteratively training the repeat-ablation efficacy machine-learning model using the training data, wherein ablation evaluation machine-learning model is trained and retrained until it surpasses an accuracy threshold, wherein new patient data is periodically integrated into the training data;

inputting, into the repeat-ablation efficacy machine-learning model, the post-ablation arrhythmic ECG data; and

receiving as output, from the repeat-ablation efficacy machine-learning model, the repeat-ablation efficacy data;

transmitting, by the at least a processor, for display, the repeat-ablation efficacy data;

generating, using a treatment machine-learning model, a treatment recommendation based on the repeat-ablation efficacy data, the treatment recommendation comprising performing a repeat ablation procedure at a secondary ablation target on the patient; and

performing the repeat ablation procedure at the secondary ablation target on the patient according to the generated treatment recommendation to increase a likelihood of success of the repeat ablation procedure.

12. The method of claim 11 , wherein the repeat-ablation efficacy data comprises a predicted chance of pulmonary vein reconnection.

13. The method of claim 11 , wherein generating the ablation training data from the subset of patient health records comprises de-identifying the subset of patient health records.

14. The method of claim 11 , wherein the repeat-ablation efficacy data comprises a quantitative value or a classification.

15. The method of claim 11 , wherein determining the treatment recommendation comprises generating, using the treatment machine-learning model, the treatment recommendation as a function of the post-ablation arrhythmic ECG data.

16. The method of claim 15 , wherein determining a treatment recommendation comprises:

receiving treatment training data, wherein the treatment training data comprises historical ECG data correlated to historical treatment data;

training the treatment machine-learning model using the treatment training data; and

generating the treatment recommendation using the trained treatment machine-learning model.

17. The method of claim 15 further comprising displaying, using a display device, the treatment recommendation.

18. The method of claim 15 , further comprising:

receiving, by the at least a processor, a post-recommended treatment ECG and recommended treatment outcome data; and

retraining, by the at least a processor, the treatment machine-learning model as a function of the post-recommended treatment ECG and the recommended treatment outcome data.

19. The method of claim 1 , wherein:

the method further comprises receiving, by the at least a processor, prior-procedure intracardiac echocardiogram data; and

generating the repeat-ablation efficacy data of the patient further comprises inputting, into the repeat-ablation efficacy machine-learning model, the prior-procedure intracardiac echocardiogram data.

20. The method of claim 11 , wherein:

the method further comprises receiving, by the at least a processor, prior-procedure ablation parameter data; and

generating the repeat-ablation efficacy data of the patient further comprises inputting, into the repeat-ablation efficacy machine-learning model, the prior-procedure ablation parameter data.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2024
From: VAIDYA, SUTHIRTH; BARVE, RAKESH; AGARWAL, ANIMESH; AWASTHI, SAMIR; ARAVAMUDAN, MURALI; NANAVATY, MAULIK
To: ANUMANA, INC.
Reel/Frame 068732/0279 →
References Cited (13)
US 10154888B2 · Sagon et al. · 2018 [cited by applicant]
US 11540796B2 · Madabhushi et al. · 2023 [cited by applicant]
US 11922630B2 · Trayanova et al. · 2024 [cited by applicant]
US 20200060757A1 · Ben-Haim · 2020 [cited by examiner]
US 20210085387A1 · Amit · 2021 [cited by examiner]
US 20220044787A1 · Kaufman · 2022 [cited by examiner]
US 20220079499A1 · Doron · 2022 [cited by examiner]
US 20220101530A1 · Trayanova · 2022 [cited by examiner]
US 20240112819A1 · Paamand et al. · 2024 [cited by applicant]
Tang et al., “Machine Learning-Enabled Multimodal Fusion of Intra-Atrial and Body Surface Signals in Prediction of Atrial Fibrillation Ablation Outcomes,” Circ Arrhythm Electrophysiol. 2022;15:e010850. DOI: 10.1161/CIRC… [cited by examiner]
Wojcik et al., “Repeated Catheter Ablation of Atrial Fibrillation—How to Predict Outcome?—,” Circulation Journal vol. 77, Sep. 2013; doi: 10.1253/circj.CJ-13-0308. (Year: 2013). [cited by examiner]
Kornej et al., “The APPLE Score—A Novel Score for the Prediction of Rhythm Outcomes after Repeat Catheter Ablation of Atrial Fibrillation,” PLoS ONE 12(1): e0169933; doi:10.1371/journal.pone.0169933. (Year: 2017). [cited by examiner]
Jan De Pooter et al; Validation of a machine learning algorithm to identify pulmonary vein isolation during ablation procedures for the treatment of atrial fibrillation: results of the PVISION study; Europace. May 2024;… [cited by applicant]