IP Library Granted Patent US 12,377,023
Granted Patent B1
US 12,377,023 · App. 18/965,473 · Granted Aug 5, 2025

Fluid transfer device

Inventors: Haiming Wu (Weston, MA); Danial Ferreira (Shelton, CT)
Assignee: Genzyme Corporation
A61J1/2096
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,377,023
App. No.
18/965,473
Granted
Aug 5, 2025
Kind
B1
Abstract

A fluid transfer device comprises a body comprising a first connecting portion comprising a first fluid channel to fluidically communicate with an interior of a diluent container, a second connecting portion comprising a second fluid channel to fluidically communicate with an interior of a medicament container, a third connecting portion comprising a third fluid channel to fluidically communicate with an interior of a pooling container, and a fourth fluid channel to fluidically communicate with a pump device. A movable part is engaged with and movable relative to the body to transfer the fluid transfer device into one of a first configuration, a second configuration and a third configuration. When in the first configuration, the second fluid channel is fluidically coupled to the third fluid channel, and when in the second configuration, the first fluid channel is fluidically connectable to the third fluid channel.

Claims (36)

1. A fluid transfer device for transferring a fluid between a diluent container, a medicament container, and a pooling container, the fluid transfer device comprising:

a body comprising:

a first connecting portion configured to connect to the diluent container and comprising a first fluid channel configured to fluidically communicate with an interior of the diluent container;

a second connecting portion configured to connect to the medicament container and comprising a second fluid channel configured to fluidically communicate with an interior of the medicament container;

a third connecting portion configured to connect to the pooling container and comprising a third fluid channel configured to fluidically communicate with an interior of the pooling container; and

a fourth fluid channel configured to fluidically communicate with a pump device; and

a movable part engaged with the body and movable relative to the body to transfer the fluid transfer device into one of a first configuration, a second configuration, and a third configuration,

wherein when in the first configuration, the second fluid channel is fluidically coupled to the third fluid channel to allow a flow of fluid from the medicament container into the pooling container, and

wherein when in the second configuration, the first fluid channel is fluidically connectable to the third fluid channel to allow a flow of fluid from the diluent container into the pooling container.

2. The fluid transfer device according to claim 1 , wherein when in the second configuration, a flow of fluid from the pooling container into the diluent container is prevented.

3. The fluid transfer device according to claim 1 , wherein when in the third configuration, the second fluid channel is fluidically connectable to the third fluid channel to allow a flow of fluid from the pooling container into the diluent container.

4. The fluid transfer device according to claim 1 , wherein when in the third configuration, a flow of fluid from the diluent container into the pooling container is prevented.

5. The fluid transfer device according to claim 1 , wherein the fluid transfer device is transferable into the first configuration, the second configuration, and/or the third configuration by moving the movable part into a first position, a second position, and/or a third position relative to the body.

6. The fluid transfer device according to claim 1 , wherein the movable part comprises a first transfer channel with a first passageway, wherein the first transfer channel is aligned and fluidically coupled with the second fluid channel and with the third fluid channel when the fluid transfer device is in the first configuration.

7. The fluid transfer device according to claim 1 , wherein the movable part comprises a second transfer channel that is aligned and fluidically coupled with the first fluid channel and with the third fluid channel, wherein the second transfer channel is configured to allow a flow of fluid from the first fluid channel into the third fluid channel when the fluid transfer device is in the second configuration.

8. The fluid transfer device according to claim 7 , wherein the second transfer channel comprises:

a second passageway comprising a distal end aligned and fluidically coupled with the first fluid channel, and a proximal end aligned and fluidically connectable with the fourth fluid channel, when the fluid transfer device is in the second configuration; and

a first branch section merging into the second passageway and fluidically connectable with the third fluid channel when the fluid transfer device is in the second configuration.

9. The fluid transfer device according to claim 1 , wherein the movable part comprises a third transfer channel that is aligned and fluidically coupled with the first fluid channel and with the third fluid channel, and wherein the third transfer channel is configured to allow a flow of fluid from the third fluid channel into the first fluid channel when the fluid transfer device is in the third configuration.

10. The fluid transfer device according to claim 9 , wherein the third transfer channel comprises:

a third passageway comprising a distal end aligned and fluidically coupled with the first fluid channel, and a proximal end aligned and fluidically connectable with the fourth fluid channel when the fluid transfer device is in the third configuration; and

a second branch section merging into the third passageway and fluidically connectable with the third fluid channel when the fluid transfer device is in the third configuration.

11. The fluid transfer device according to claim 1 , wherein the fourth fluid channel is fluidically coupled with at least one of the first fluid channel and the third fluid channel when the fluid transfer device is in one of the second configuration and the third configuration.

12. The fluid transfer device according to claim 1 , wherein the body comprises a cavity confined by a sidewall and defining a longitudinal direction, and wherein one or more of the first fluid channel, the second fluid channel, the third fluid channel, and the fourth fluid channel extends through the sidewall and merges into the cavity.

13. The fluid transfer device according to claim 12 , wherein the movable part comprises an insert portion that is movably arranged inside the cavity.

14. The fluid transfer device according to claim 12 , wherein the fluid transfer device is transferable between the first configuration, the second configuration, and the third configuration by moving the movable part inside the cavity in the longitudinal direction relative to the body.

15. A method of administering an injectable medicament, the method comprising:

preparing the injectable medicament by transferring a fluid between a diluent container, a medicament container, and a pooling container by using a fluid transfer device, wherein the fluid transfer device comprises:

a body comprising:

a first connecting portion configured to connect to the diluent container, the first connecting portion comprising a first fluid channel configured to fluidically communicate with an interior of the diluent container;

a second connecting portion configured to connect to the medicament container, the second connecting portion comprising a second fluid channel configured to fluidically communicate with an interior of the medicament container;

a third connecting portion configured to connect to the pooling container, the third connecting portion comprising a third fluid channel configured to fluidically communicate with an interior of the pooling container; and

a fourth fluid channel configured to fluidically communicate with a pump device; and

a movable part engaged with the body and movable relative to the body to transfer the fluid transfer device into one of a first configuration, a second configuration, and a third configuration,

wherein when in the first configuration, the second fluid channel is fluidically coupled to the third fluid channel to allow a flow of fluid from the medicament container into the pooling container, and

wherein when in the second configuration, the first fluid channel is fluidically connectable to the third fluid channel to allow a flow of fluid from the diluent container into the pooling container.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2025
From: FERREIRA, DANIAL
To: START LLC
Reel/Frame 071165/0245 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2025
From: START LLC
To: GENZYME CORPORATION
Reel/Frame 071165/0422 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2025
From: WU, HAIMING
To: GENZYME CORPORATION
Reel/Frame 071165/0622 →
References Cited (47)
US 4997430A · Van der Heiden et al. · 1991 [cited by applicant]
US 5466220A · Brenneman · 1995 [cited by applicant]
US 6474375B2 · Spero et al. · 2002 [cited by applicant]
US 6478771B1 · Lavi et al. · 2002 [cited by applicant]
US 6558365B2 · Zinger et al. · 2003 [cited by applicant]
US 7326194B2 · Zinger et al. · 2008 [cited by applicant]
US 7896849B2 · Delay · 2011 [cited by applicant]
US 8425487B2 · Beiriger et al. · 2013 [cited by applicant]
US 8562584B2 · Beiriger et al. · 2013 [cited by applicant]
US 9132061B2 · Beiriger · 2015 [cited by applicant]
US 9339438B2 · Lev et al. · 2016 [cited by applicant]
US 9345643B2 · Okiyama · 2016 [cited by applicant]
US 10420927B2 · Fangrow · 2019 [cited by applicant]
US 10688295B2 · Lev et al. · 2020 [cited by applicant]
US 10765604B2 · Denenburg et al. · 2020 [cited by applicant]
US 10945921B2 · Denenburg · 2021 [cited by applicant]
US 11642285B2 · Deneburg et al. · 2023 [cited by applicant]
US 11786443B2 · Lev et al. · 2023 [cited by applicant]
US 12161839B1 · Lau · 2024 [cited by examiner]
US 12171719B1 · Wu et al. · 2024 [cited by applicant]
US 12213944B1 · Wu et al. · 2025 [cited by applicant]
US 12226371B1 · Wu et al. · 2025 [cited by applicant]
US 20080269680A1 · Ibranyan et al. · 2008 [cited by applicant]
US 20110087164A1 · Mosler et al. · 2011 [cited by applicant]
US 20190381237A1 · Desbrosses et al. · 2019 [cited by applicant]
US 20210154097A1 · McLoughlin et al. · 2021 [cited by applicant]
US 20210228446A1 · Herrmann · 2021 [cited by applicant]
US 20230052165A1 · Bar-El et al. · 2023 [cited by applicant]
US 20230321337A1 · Levy · 2023 [cited by examiner]
EP 2842540A1 · 2015 [cited by applicant]
WO WO2004058820A2 · 2004 [cited by applicant]
WO WO2004068820A2 · 2004 [cited by applicant]
WO WO2005018629A1 · 2005 [cited by applicant]
WO WO2006003388A2 · 2006 [cited by applicant]
WO WO2006030220A1 · 2006 [cited by applicant]
WO WO2007017868A1 · 2007 [cited by applicant]
WO WO2020208626A1 · 2020 [cited by applicant]
Hamers-Casterman et al., “Naturally occurring antibodies devoid of light chains,” Nature, Jun. 3, 1993, 363(6428):446-448. [cited by applicant]
Holt et al., “Domain antibodies: proteins for therapy,” Trends in Biotechnology, Nov. 2003, 21(11):484-490. [cited by applicant]
Muyldermans, “Single domain camel antibodies: current status,” Reviews in Molecular Biotechnology, Jun. 2001, 74(4):277-302. [cited by applicant]
Needle-based injection systems for medical use Requirements and test methods, Part 1: Needle injection systems, ISO 11608-1:2014(E), Third Edition, Switzerland, ISO, Dec. 15, 2014, pp. 1-13. [cited by applicant]
Ward et al., “Binding activities of a repertoire of single immunoglobulin variable domains secreted from [cited by applicant]
U.S. Appl. No. 18/666,279, filed May 16, 2024, Haiming Wu. [cited by applicant]
U.S. Appl. No. 18/666,379, filed May 16, 2024, Haiming Wu. [cited by applicant]
U.S. Appl. No. 18/666,417, filed May 16, 2024, Haiming Wu. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2024/061704, mailed on May 2, 2025, 17 pages. [cited by applicant]
International Search Report and Written Opinion in International Appln. No. PCT/US2025/010525, mailed on Apr. 25, 2025, 16 pages. [cited by applicant]