Treatment of diseases associated with biliary system destruction
The present invention relates to the field of neonatal cholestasis, in particular the treatment of neonatal biliary atresia or diseases associated with biliary system destruction. Also, the invention relates to methods and/or compounds for treating or preventing biliary atresia or disease associated with biliary system destruction. It further relates to methods and/or compounds for slowing the progression of biliary atresia or disease associated with biliary system destruction.
1. A method of treatment comprising administering to a patient after hepatoportoenterostomy, an effective amount of a fibrate compound comprising an agonist of the alpha form of PPAR for treatment of biliary atresia.
2. The method according to claim 1 , wherein administering the fibrate compound slows progression of biliary atresia in the patient.
3. The method according to claim 1 , wherein said agonist of the alpha form of PPAR is not elafibranor.
4. The method according to claim 3 , wherein the fibrate compound comprises one or more compounds selected from the group consisting of fenofibrate, ciprofibrate, gemfibrozil, bezafibrate, clinofibrate, clofibrate, clofibride, ronifibrate and simfibrate.
5. The method according to claim 4 , wherein the fibrate compound is fenofibrate or bezafibrate.
6. The method according to claim 4 , wherein the fibrate compound is a combination of compounds selected from the group consisting of fenofibrate, ciprofibrate, gemfibrozil, bezafibrate, clinofibrate, clofibrate, clofibride, ronifibrate and simfibrate.
7. The method according to claim 4 , wherein the fibrate compound is a combination of fenofibrate and bezafibrate.
8. The method according to claim 4 , wherein the one or more compounds are formulated separately and co-administered to the subject.
9. The method according to claim 1 , said patient being a neonate or an infant.
10. The method according to claim 1 , wherein the fibrate compound is administered to the patient once a day.
11. The method according to claim 10 , wherein the fibrate compound is administered to the patient before a night fast.
12. The method according to claim 1 , said fibrate compound being administered to the patient in the form of a pharmaceutical composition.
13. The method according to claim 1 , wherein the fibrate compound is administered to the patient every 12 hours.
14. The method according to claim 1 , wherein the amount of the fibrate compound is sufficient to restore an effective autophagic clearance in the patient.