Compositions containing nicotinamide and vitamin B6 and methods of using such compositions for treating sarcopenia and frailty
A composition contains Nicotinamide and pyridoxine. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof orally or intravenously for preventing and/or treating sarcopenia, physical frailty, a loss of and/or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength and/or skeletal muscle function.
1 . A method for treating sarcopenia and/or physical frailty, and/or improving skeletal muscle mass, skeletal muscle lean mass, skeletal muscle strength and/or skeletal muscle function in an individual in need thereof, the method comprising administering to the individual a therapeutically effective amount of a composition comprising a combination of Vitamin B6 and Nicotinamide in a weight ratio of from about 1:80 to about 1:20.
2 . The method according to claim 1 , wherein the Vitamin B6 is administered in an amount of 1.0-600 mg vitamin B6 per day.
3 . The method according to claim 1 , wherein the Nicotinamide is administered in an amount of about 1 mg/day to about 3000 mg/day.
4 . The method according to claim 1 , wherein the Vitamin B6 is administered in an amount of 10-20.0 mg vitamin B6 per day, and the Nicotinamide is administered in an amount of about 500 mg to about 1000 mg Nicotinamide per day.
5 . The method according to claim 1 , wherein the Vitamin B6: Nicotinamide are present in a weight ratio of from about 1:100-60 to about 1:930.
6 . The method according to claim 1 , wherein the Vitamin B6: Nicotinamide are present in a weight ratio of from about 1:45 to about 1:30.
7 . The method according to claim 1 , wherein the composition is in a form selected from the group consisting of an oral nutritional composition, a nutritional supplement, an oral nutritional supplement, a medical food, a food supplement, a food product, and a food for special medical purpose (FSMP).
8 . The method according to claim 1 , wherein the composition is in a form selected from the group consisting of a solid powder, a powdered stick, a capsule and a solution.
9 . The method according to claim 1 , wherein the individual has sarcopenia or is at risk thereof, and the administering of the therapeutically effective amount of the composition restores and/or corrects deficiencies of nutrients in the individual.
10 . The method according to claim 1 , wherein the individual is selected from the group consisting of an aging subject; an elderly subject; a subject with muscle fatigue or muscle weakness; a subject with impaired mobility; a frail subject; a pre-frail subject; a sarcopenic subject; and a subject recovering from pre-frailty, frailty, sarcopenia and impaired mobility.
11 . The method according to claim 1 , wherein the composition is a food product further comprising a component selected from the group consisting of protein, carbohydrate, fat and mixtures thereof.
12 . The method according to claim 1 , wherein the administering of the therapeutically effective amount of the composition treats sarcopenia in the individual.
13 . The method according to claim 1 , wherein the administering of the therapeutically effective amount of the composition treats physical frailty in the individual.
14 . The method according to claim 1 , the administering of the therapeutically effective amount of the composition improves skeletal muscle mass, skeletal muscle lean mass, skeletal muscle strength and/or skeletal muscle function in the individual.
15 . The method according to claim 1 , wherein the Vitamin B6 is administered in an amount of 10-20.0 mg vitamin B6 per day.
16 . The method according to claim 1 , wherein the Nicotinamide is administered in an amount of about 500 mg to about 1000 mg Nicotinamide per day.