IP Library Granted Patent US 12,697,293
Granted Patent B2
US 12,697,293 · App. 17/771,631 · Granted Aug 4, 2026

Natural skincare compositions

Inventors: Sean Farmer (Ft. Lauderdale, FL); Ken Alibek (Solon, OH)
Assignee: LOCUS SOLUTIONS IPCO, LLC
A61K8/604A61K8/06A61K8/35A61K8/361A61Q19/04
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,697,293
App. No.
17/771,631
Filed
Apr 25, 2022
Granted
Aug 4, 2026
Kind
B2
Art Unit
1693
USPC
514/53
Abstract

The topical cosmetic compositions and methods of the subject invention can be used to improve the health and/or appearance of skin by, for example, treating and/or preventing a variety of skin conditions. The invention also provides compositions and methods for enhanced sunless tanning. Biological amphiphilic molecules are used as active components, formulation enhancers and/or delivery vessels for skin active components.

Claims (8)

1 . A method for improving the health and/or appearance of a subject's skin, wherein the method comprises applying, directly to the subject's skin, a topical composition consisting essentially of:

sophorolipids (SLPs);

an oat extract or salicylic acid;

one of cetyl alcohol, cetearyl alcohol, stearyl alcohol, pentylene glycol, vitamin A, and tocopherol, and

a dermatologically-acceptable carrier;

wherein the sophorolipids are present in an amount from 1.0% to 15% by weight and are present in a ratio of linear to lactonic SLP of 0:1 to 1:10, and

wherein the improved skin health and/or appearance is reduction in wrinkles, crow's feet, dark eye circles, blemishes, age spots, or a reduction in psoriasis, eczema, dermatitis, sunburn, rosacea, insect bites or stings, atopic dermatitis, and chronic wounds.

2 . The method of claim 1 , wherein the composition further comprises a mannosylerythritol lipid (MEL).

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Nov 18, 2024
From: U.S. BANK TRUST COMPANY
To: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC,; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC,; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
Reel/Frame 069386/0272 →
SECURITY INTEREST Recorded Nov 11, 2024
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 069333/0911 →
RELEASE OF SECURITY INTEREST Recorded Oct 30, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 069273/0361 →
SECURITY INTEREST Recorded Dec 8, 2023
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS THE COLLATERAL AGENT
Reel/Frame 065836/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2023
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 065615/0905 →
SECURITY INTEREST Recorded Dec 7, 2022
From: LOCUS SOLUTIONS, LLC; LOCUS MANAGEMENT GP, INC.; LOCUS MANAGEMENT, LLC; LOCUS IP COMPANY, LLC; LOCUS OIL HOLDING, LLC; LOCUS BIO-ENERGY SOLUTIONS, LLC; LOCUS OIL IP COMPANY, LLC; LOCUS AGRICULTURE HOLDING, LLC; LOCUS AGRICULTURAL SOLUTIONS, LLC; LOCUS AGRICULTURE IP COMPANY, LLC; LOCUS SOLUTIONS IPCO, LLC; LOCUS SOLUTIONS IPHOLDCO, LLC; LOCUS CONSUMER BRANDS HOLDING, LLC; ARCTIVA WELLNESS, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 062079/0829 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 3, 2022
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 062054/0132 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2022
From: FARMER, SEAN; ALIBEK, KEN
To: LOCUS IP COMPANY, LLC
Reel/Frame 059898/0402 →
Continuity (2)
Provisional Application 63064468 · Aug 12, 2020
Related Publication 20230157938A1 · May 25, 2023
References Cited (173)
US 4902512A · Ishigami et al. · 1990 [cited by applicant]
US 5487899A · Davis · 1996 [cited by applicant]
US 5756471A · Hillion et al. · 1998 [cited by applicant]
US 5981497A · Maingault · 1999 [cited by applicant]
US 6057302A · Borzeix · 2000 [cited by applicant]
US 6403108B1 · Abdullah · 2002 [cited by applicant]
US 6596265B1 · Borzeix Concaix · 2003 [cited by applicant]
US 6699499B1 · Aneja · 2004 [cited by applicant]
US 6759057B1 · Weiner et al. · 2004 [cited by applicant]
US 9271908B2 · Allef et al. · 2016 [cited by applicant]
US 9289460B2 · Justen et al. · 2016 [cited by applicant]
US 9499419B2 · de Rijk · 2016 [cited by applicant]
US 9561255B2 · Iwama et al. · 2017 [cited by applicant]
US 9585903B2 · Prabhune et al. · 2017 [cited by applicant]
US 9650405B2 · Gross et al. · 2017 [cited by applicant]
US 9931309B2 · Singh et al. · 2018 [cited by applicant]
US 10065982B2 · Hirata et al. · 2018 [cited by applicant]
US 10307466B2 · Suzuki et al. · 2019 [cited by applicant]
US 20020123077A1 · O'Toole et al. · 2002 [cited by applicant]
US 20030050277A1 · Kajimoto et al. · 2003 [cited by applicant]
US 20070116750A1 · Wolcott · 2007 [cited by applicant]
US 20080311234A1 · Yoneda et al. · 2008 [cited by applicant]
US 20090203649A1 · Kato et al. · 2009 [cited by applicant]
US 20100004472A1 · Kitagawa et al. · 2010 [cited by applicant]
US 20100168405A1 · Suzuki et al. · 2010 [cited by applicant]
US 20100216197A1 · Shiraishi et al. · 2010 [cited by applicant]
US 20100267684A1 · Seong et al. · 2010 [cited by applicant]
US 20100280111A1 · Aoki · 2010 [cited by examiner]
US 20110044972A1 · Fieldhouse et al. · 2011 [cited by applicant]
US 20110237531A1 · Yanagisawa et al. · 2011 [cited by applicant]
US 20120311741A1 · Soetaert et al. · 2012 [cited by applicant]
US 20140127257A1 · Schiemann et al. · 2014 [cited by applicant]
US 20140178444A1 · Stadler et al. · 2014 [cited by applicant]
US 20140296168A1 · Schilling et al. · 2014 [cited by applicant]
US 20140323757A1 · Kim · 2014 [cited by applicant]
US 20140364381A1 · Ju et al. · 2014 [cited by applicant]
US 20150037302A1 · Bralkowski et al. · 2015 [cited by applicant]
US 20150044317A1 · Farmer et al. · 2015 [cited by applicant]
US 20150045290A1 · Coutte et al. · 2015 [cited by applicant]
US 20150094273A1 · Prabhune et al. · 2015 [cited by applicant]
US 20160030322A1 · Lu et al. · 2016 [cited by applicant]
US 20160083757A1 · Fonseca et al. · 2016 [cited by applicant]
US 20160101211A1 · Zimnitsky et al. · 2016 [cited by applicant]
US 20160199530A1 · Ploger et al. · 2016 [cited by applicant]
US 20160213757A1 · Edelson et al. · 2016 [cited by applicant]
US 20160280733A1 · Araki et al. · 2016 [cited by applicant]
US 20160309715A1 · Diaz de Rienzo et al. · 2016 [cited by applicant]
US 20160324747A1 · Ito et al. · 2016 [cited by applicant]
US 20160375071A1 · Figueroa et al. · 2016 [cited by applicant]
US 20170087199A1 · Patron et al. · 2017 [cited by applicant]
US 20170119638A1 · Kondo et al. · 2017 [cited by applicant]
US 20170143753A1 · Gross et al. · 2017 [cited by applicant]
US 20170172913A1 · Ballesteros et al. · 2017 [cited by applicant]
US 20180264051A1 · Prabhune et al. · 2018 [cited by applicant]
US 20180310566A1 · Sawyer et al. · 2018 [cited by applicant]
US 20190231668A1 · Yoo et al. · 2019 [cited by applicant]
US 20190307788A1 · Wakayama · 2019 [cited by applicant]
US 20190359562A1 · Lyman et al. · 2019 [cited by applicant]
US 20200155444A1 · Farmer · 2020 [cited by examiner]
US 20230405127A1 · Lefkowitz et al. · 2023 [cited by applicant]
CN 102465150A · 2012 [cited by applicant]
CN 103800224A · 2014 [cited by applicant]
CN 104178538A · 2014 [cited by applicant]
CN 106890114A · 2017 [cited by applicant]
DE 10131796A1 · 2003 [cited by applicant]
EP 1212093A0 · 2002 [cited by applicant]
EP 1228752A2 · 2002 [cited by applicant]
EP 1964546A1 · 2009 [cited by applicant]
EP 2351847A1 · 2011 [cited by applicant]
EP 3117838A1 · 2017 [cited by applicant]
GB 2576636A · 2020 [cited by applicant]
JP 0710735A · 1995 [cited by applicant]
JP 10501260A · 1998 [cited by applicant]
JP 2003040767A · 2003 [cited by applicant]
JP 2003113040A · 2003 [cited by applicant]
JP 2006131589A · 2006 [cited by applicant]
JP 2007129973A · 2007 [cited by applicant]
JP 2008044855A · 2008 [cited by applicant]
JP 2009029788A · 2009 [cited by applicant]
JP 2009149566A · 2009 [cited by applicant]
JP 4452799B2 · 2010 [cited by applicant]
JP 2012051872A · 2012 [cited by applicant]
JP 2014034552A · 2014 [cited by applicant]
JP 2014058500A · 2014 [cited by applicant]
JP 2014114291A · 2014 [cited by applicant]
JP 2014150774A · 2014 [cited by applicant]
KR 20110012699A · 2011 [cited by applicant]
KR 101125189B1 · 2012 [cited by applicant]
KR 101608687B1 · 2016 [cited by applicant]
RU 2185147C2 · 2002 [cited by applicant]
WO 9631190 · 1996 [cited by applicant]
WO 9850523 · 1998 [cited by applicant]
WO 9949876 · 1999 [cited by applicant]
WO 0054575A2 · 2000 [cited by applicant]
WO 2004020647A1 · 2004 [cited by applicant]
WO 2011008570A2 · 2011 [cited by applicant]
WO 2011127101A1 · 2011 [cited by applicant]
WO 2011134998A1 · 2011 [cited by applicant]
WO 2012088276A2 · 2012 [cited by applicant]
WO 2013003291A2 · 2013 [cited by applicant]
WO 2013092421A1 · 2013 [cited by applicant]
WO 2013112875A1 · 2013 [cited by applicant]
WO 2014095367A1 · 2014 [cited by applicant]
WO 2014120247A1 · 2014 [cited by applicant]
WO 2015153476A1 · 2015 [cited by applicant]
WO 2017044953A1 · 2017 [cited by applicant]
WO 2018049182A2 · 2018 [cited by applicant]
WO 2018129299A1 · 2018 [cited by applicant]
WO 2018208530A1 · 2018 [cited by applicant]
WO 2019051380A1 · 2019 [cited by applicant]
WO 2019133555A1 · 2019 [cited by applicant]
WO 2019227034A1 · 2019 [cited by applicant]
WO 2020154712A1 · 2020 [cited by applicant]
WO 2020185858A1 · 2020 [cited by applicant]
WO 2021236904A1 · 2021 [cited by applicant]
WO 2022174190A1 · 2022 [cited by applicant]
WO 2022210011A1 · 2022 [cited by applicant]
Lourith et al., International Journal of Cosmetic Science, 2009, 31, 255-261. [cited by examiner]
Arif, Clinical Cosmetic and Investigational Dermatology, 2015, 8, 455-461. [cited by examiner]
Sacchidanand et al., Clinical Dermatology Review, 2018, 2(2), 52-63. [cited by examiner]
Shapiro et al., Nutrition, 2001, 17, 839-844. [cited by examiner]
Eisenstaedt, Journal of American Medical Association, 1920, 74(10), 667-671. [cited by examiner]
Ahn, C. et al. “Tuning surface-active properties of bio-surfactant sophorolipids by varying fatty-acid chain lengths.” Korean Journal of Chemical Engineering 33 (2016): 2127-2133. [cited by applicant]
Bhadoriya, S.S., et al., “Biosurfactants: A New Pharmaceutical Additive for Solubility Enhancement and Pharmaceutical Development.” Biochemistry & Pharmacology: Open Access, 2013, 2(2): 1-5. [cited by applicant]
Bhangale, A. P., et al. “Sophorolipids synthesized using non-traditional oils with glycerol and studies on their surfactant properties with synthetic surfactant.” Tenside Surfactants Detergents 51.5 (2014): 387-396. [cited by applicant]
Bhangale, A., et al. “Production of sophorolipids synthesized on castor oil with glucose and glycerol by using Starmerella bombicola (ATCC 22214).” European Journal of Lipid Science and Technology 116.3 (2014): 336-343. [cited by applicant]
Bisht, K.S., et al. “Enzyme-mediated regioselective acylations of sophorolipids.” The Journal of Organic Chemistry 64.3 (1999): 780-789. [cited by applicant]
Ciesielska, K., et al. “Exoproteome analysis of Starmerella bombicola results in the discovery of an esterase required for lactonization of sophorolipids.” Journal of proteomics 98 (2014): 159-174. [cited by applicant]
De Brito, D., Biosurfactants from renewable raw materials, Universidade do Minho Departamento de Engenharia Biologica, Nov. 2013, pp. 1-93. [cited by applicant]
Delbeke, E. I. P., et al. “A new class of antimicrobial biosurfactants: quaternary ammonium sophorolipids.” Green Chemistry 17.6 (2015): 3373-3377. [cited by applicant]
Delbeke, E. I. P., et al. “Chemical and enzymatic modification of sophorolipids.” Green Chemistry 18.1 (2016): 76-104. [cited by applicant]
De Oliveira, M., et al., “Review: Sophorolipids A Promising Biosurfactant and it's Applications.” International Journal of Advanced Biotechnology and Research, 2015, 6(2): 161-174. [cited by applicant]
Fan, L.L., et al. “Production and identification of mannosylerythritol lipid-A homologs from the ustilaginomycetous yeast Pseudozyma aphidis ZJUDM34.” Carbohydrate research 392 (2014): 1-6. [cited by applicant]
Faria, N. T., et al. “Production of glycolipid biosurfactants, mannosylerythritol lipids, from pentoses and d-glucose/d- xylose mixtures by Pseudozyma yeast strains.” Process Biochemistry 49.11 (2014): 1790-1799. [cited by applicant]
Imura, T., et al. “Spontaneous vesicle formation from sodium salt of acidic sophorolipid and its application as a skin penetration enhancer.” Journal of oleo science 63.2 (2014): 141-147. [cited by applicant]
Ines, M., et al. “Glycolipid biosurfactants: Potential related biomedical and biotechnological applications.” Carbohydrate Research 416 (2015): 59-69. [cited by applicant]
Ishii, N., et al., “Transdermal administration of lactoferrin with sophorolipid.” Biochemistry and Cell Biology, 90.3 (2012): Abstract. [cited by applicant]
Joshi-Navare, K., et al., “A biosurfactant-sophorolipid acts in synergy with antibiotics to enhance their efficiency.” BioMed research international, 2013.1 (2013): 1-8. [cited by applicant]
Kim, K., et al., “Characteristics of Sophorolipid as an Antimicrobial Agent.” J. Microbiol. Biotechnol., 2002, 12(2): 235-241. [cited by applicant]
Kim, K., et al. “Characteristics of sophorolipid as an antimicrobial agent.” Journal of microbiology and biotechnology 12.2 (2002): 235-241. [cited by applicant]
Kitamoto, D., et al., “Self-assembling properties of glycolipid biosurfactants and their potential applications.” Current Opinion in Colloid & Interface Science, 14.5 (2009): 315-328. [cited by applicant]
Konishi, M., et al., “Efficient production of acid-form sophorolipids from waste glycerol and fatty acid methyl esters by Candida floricola.” Journal of Oleo Science, 67.4 (2018): 489-496. [cited by applicant]
Kulakovskaya E., et al., “Chapter 1—Structure and Occurrence of Yeast Extracellular Glycolipids.” Extracellular glycolipids of yeasts: biodiversity, biochemistry, and prospects. Academic Press, 2013, 1-13. [cited by applicant]
ScienceDirect Topics, “Critical Micelle Concentration.” ScienceDirect, retrieved from Internet Oct. 24, 2023 <https://www.sciencedirect.com/topics/immunology-and-microbiology/crtical-micelle-concentration>, pp. 1-13. [cited by applicant]
Kurtzman, C. P., et al., “Production of sophorolipid biosurfactants by multiple species of the [cited by applicant]
Lourith, N., et al., “Natural surfactants used in cosmetics: glycolipids.” International journal of cosmetic science, 31.4 (2009): 255-261. [cited by applicant]
Lydon, H. L., et al., “Adjuvant antibiotic activity of acidic sophorolipids with potential for facilitating wound healing.” Antimicrobial agents and chemotherapy, 61.5, e02547 (2017): 1-9. [cited by applicant]
Madankar, C. S., et al., “Review on sophorolipids—a promising microbial bio-surfactant.” Tenside Surfactants Detergents, 60.2 (2023): 95-105. [cited by applicant]
Meena, K.R., et al., “Lipopeptides as the antifungal and antibacterial agents: applications in food safety and therapeutics.” BioMed research international, 2015.1, 473050 (2015): 1-9. [cited by applicant]
Mintel: “GNPD—Moisturizer.” Retrieved from Internet: Mar. 15, 2021, <https://www.gnpd.com/sinatra/recordpage/4643835/> pp. 1-2. [cited by applicant]
Mintel: “GNPD—Reparation U.V. Soothing After-Sun Care for Face.” Retrieved from Internet: Mar. 15, 2021, <https://www.gnpd.com/sinatra/recordpage/3274251/> pp. 1-3. [cited by applicant]
Morita, T., et al., “Mannosylerythritol lipids: production and applications.” Journal of Oleo Science, 64.2 (2015): 133-141. [cited by applicant]
Roelants, S.L.K.W., et al., “Towards the industrialization of new biosurfactants: biotechnological opportunities for the lactone esterase gene from Starmerella bombicola.” Biotechnology and bioengineering, 113.3 (2016):… [cited by applicant]
Rowan, M.P., et al., “Burn wound healing and treatment: review and advancements.” Critical care, 19 (2015): 1-12. [cited by applicant]
Saerens, K.M.J., et al., “One-step production of unacetylated sophorolipids by an acetyltransferase negative Candida bombicola.” Biotechnology and bioengineering, 108.12 (2011): 2923-2931. [cited by applicant]
Santos, D.K.F., et al., “Biosurfactants: multifunctional biomolecules of the 21st century.” International journal of molecular sciences, 17.3 (2016): 1-31. [cited by applicant]
Sen, R., “Biosurfactants: Advances in Experimental Medicine and Biology.” Landes Bioscience and Springer Science +Business Media, LLC, 2010, 672: 1-331. [cited by applicant]
Shen, C., et al., “Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation.” Scientific reports, 6.1, 37553 (2016): 1-10. [cited by applicant]
Sil, J., et al., “Health care applications of different biosurfactants: Review.” Int. J. Sci. Res, 6.10 (2017): 41-50. [cited by applicant]
Srivastava, R.K., et al., “Microbial originated surfactants with multiple applications: a comprehensive review.” Archives of Microbiology, 204.8, 452 (2022): 1-19. [cited by applicant]
Takahashi, M., et al., “Production of sophorolipid glycolipid biosurfactants from sugarcane molasses using Starmerella bombicola NBRC 10243.” Journal of Oleo Science, 60.5 (2011): 267-273. [cited by applicant]
Thaniyavarn, J., et al., “Production of sophorolipid biosurfactant by Pichia anomala.” Bioscience, biotechnology, and biochemistry, 72.8 (2008): 2061-2068. [cited by applicant]
Tiwari, V.K., “Burn wound: How it differs from other wounds?” Indian journal of plastic surgery, 45.02 (2012): 364-373. [cited by applicant]
Torres Faria, N., et al., “Production of glycolipid biosurfactants, mannosylerythritol lipids, from pentoses and d-glucose/d-xylose mixtures by Pseudozyma yeast strains.” Process Biochemistry, 49.11 (2014): 1790-1799. [cited by applicant]
Ueno, Y., et al., “Characterization of biosurfactant-containing liposomes and their efficiency for gene transfection.” Biological and Pharmaceutical Bulletin, 30.1 (2007): 169-172. [cited by applicant]
Van Bogaert, I. N. A., et al., “Microbial production and application of sophorolipids.” Applied microbiology and biotechnology, 76 (2007): 23-34. [cited by applicant]
Wadekar, S., et al., “Sophorolipid production by Starmerella bombicola (ATCC 22214) from virgin and waste frying oils, and the effects of activated earth treatment of the waste oils.” Journal of the American Oil Chemist… [cited by applicant]
Wang, H., et al., “Stereocontrolled syntheses of all four stereoisomeric 1, N 2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.” Organic Letters, 3.22 (2001): 3603-3605. [cited by applicant]
Wongsirichot, P., et al., “A review of sophorolipid production from alternative feedstocks for the development of a localized selection strategy.” Journal of Cleaner Production, 319 (2021): 1-23. [cited by applicant]
Zhang, Y., et al., “Semicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve-plates coupled with a novel separation system.” Microbial biotechnology, 11.3 (2018): 455-… [cited by applicant]
Gaby Mora: “Recipe: Walnut oil mayonnaise”, Nov. 28, 2020 (Nov. 28, 2020), XP93189227, Retrieved from the Internet: mURL: https://gabymora.com.au/recipe-walnutoil-mayonnaise/: pp. 1-5. [cited by applicant]
Office Action issued in Japanese Patent Application No. 2023-509784, dated Sep. 2, 2025. [cited by applicant]
Cho, W.Y., et al., “Sophorolipids—Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health”, Molecules 2022, 27, 5556. https://doi.org/10.3390/molecules27175556. [cited by applicant]