IP Library › Granted Patent US 12,708,639
Granted Patent B2
US 12,708,639 · App. 17/595,166 · Granted Aug 18, 2026

Compositions and methods to treat or prevent metabolic fatigue using the compound oleuropein or a metabolite thereof

Inventors: Umberto De Marchi (Corminboeuf, CH); Marie Noelle Horcajada (Echenevex, FR); Jerome Feige (Crissier, CH); Cristina Mammucari (Padua, IT); Bert Blaauw (Padua, IT)
Assignee: Societe des Produits Nestle S.A.
A61K31/7048A23L33/125A61P43/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,708,639
App. No.
17/595,166
Filed
Nov 10, 2021
Granted
Aug 18, 2026
Kind
B2
Art Unit
1627
USPC
514/678
Abstract

At least one of oleuropein or metabolite thereof can be orally administered to an individual in an amount effective to achieve at least one result that is one or more of (i) improvement in a physiological state linked to metabolic fatigue in one or more cells, (ii) increased mitochondrial energy and mitochondrial calcium uptake in one or more cells, and/or (iii) treatment or prevention of a calcium deficiency/depletion disorder. Additionally or alternatively, the method can treat or prevent a mitochondria-related disease or a condition associated with altered mitochondrial function in an individual in need thereof or at risk thereof.

Claims (10)

1 . A method of treatment or prevention of a calcium deficiency/depletion disorder in an individual in need thereof, the method comprising orally administering to the individual a composition comprising an effective amount of a compound selected from the group consisting of oleuropein aglycone, homovanillyl alcohol, isohomovanillyl alcohol, and combinations thereof.

2 . The method of claim 1 , wherein the composition is orally administered daily for at least one week.

3 . The method of claim 1 , wherein the composition is selected from the group consisting of food compositions, dietary supplements, nutritional compositions, nutraceuticals, beverages, powdered nutritional products to be reconstituted in water or milk before consumption, food additives, medicaments, drinks, petfood, and combinations thereof.

4 . The method of claim 1 , wherein the composition further comprises calcium.

5 . The method of claim 1 , wherein the composition is a food product further comprising a component selected from the group consisting of protein, carbohydrate, fat, and combinations thereof.

6 . The method of claim 4 , wherein the composition comprises the calcium in an amount from about 200 mg to about 800 mg.

7 . The method of claim 1 , wherein the composition is administered for a time period of at least two days per week for at least two months.

8 . The method of claim 1 , wherein at least a portion of the effective amount of the compound is in the form of an extract.

9 . The method of claim 8 , wherein the extract is an Oleaceae plant extract.

10 . The method of claim 5 , wherein the protein comprises whey protein.

Continuity (2)
Provisional Application 62847076 · May 13, 2019
Related Publication 20220202842A1 · Jun 30, 2022
References Cited (41)
US 2707152A · Chaney · 1955 [cited by examiner]
US 10751357B2 · Horcajada · 2020 [cited by examiner]
US 11364254B2 · Horcajada · 2022 [cited by examiner]
US 11813273B2 · Horcajada · 2023 [cited by examiner]
US 20060193931A1 · Coxam et al. · 2006 [cited by applicant]
US 20110112201A1 · Liu et al. · 2011 [cited by applicant]
US 20120302645A1 · Liu · 2012 [cited by examiner]
US 20130059920A1 · Friedel et al. · 2013 [cited by applicant]
US 20160045519A1 · Horcajada · 2016 [cited by examiner]
US 20180353527A1 · Horcajada et al. · 2018 [cited by applicant]
CA 3224027A1 · 2017 [cited by examiner]
CN 106213492A · 2016 [cited by examiner]
EP 1072265A1 · 2001 [cited by applicant]
JP 2017178914A · 2017 [cited by applicant]
WO WO0245524A2 · 2002 [cited by examiner]
WO 2009121600A2 · 2009 [cited by applicant]
WO 2010118789 · 2010 [cited by applicant]
WO 2014161872A1 · 2014 [cited by applicant]
WO 2015063737A1 · 2015 [cited by applicant]
WO 2019092069A2 · 2019 [cited by applicant]
WO 2020229538A1 · 2020 [cited by applicant]
WO 2020229539A1 · 2020 [cited by applicant]
U.S. Appl. No. 17/736,496, filed May 13, 2019, De Marchi; Umberto, A61K31/7048, 1/1. [cited by examiner]
Hatton et al., The human cell count and size distribution, Proc Natl Acad Sci U S A, Sep. 26, 2023; 120(39). [cited by examiner]
Hunter, n-3 fatty acids from vegetable oils, Am J Clin Nutr, 1990. [cited by examiner]
Food Sources of Vitamin D, Data Source: U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, 2019, fdc.nal.usda.gov, available at https://www.dietaryguidelines.gov/resources/2020-2025-dietary… [cited by examiner]
Fujiwara et al., Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4, J Clin Biochem Nutr. Nov. 2017;61(3):196-202. [cited by examiner]
Doehner et al., Skeletal muscle weakness is related to insulin resistance in patients with chronic heart failure, ESC Heart Fail, Jun. 2015;2(2):85-89. [cited by examiner]
Van Sickle et al., Lipids, vol. 27, No. 3, pp. 157-160, 1992. [cited by examiner]
Notification of Transmittal of the International Search Report and the Written Opinion for International Appl No. PCT/EP2023/061479 dated Aug. 4, 2023. [cited by applicant]
Chinese Office Action for Appl No. 202080029054.4 dated May 13, 2023. [cited by applicant]
Marchetti et al. “Oleuropein-Enriched Olive Leaf Extract Affects Calcium Dynamics and Impairs Viability of Malignant Mesothelioma Cells” Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medici… [cited by applicant]
Van Dronkelaar et al. “Minerals and Sarcopenia: The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A System… [cited by applicant]
Filip et al., “Twelve-Month Consumption of a Polyphenol Extract From Olive ( [cited by applicant]
Fernandez-Real et al., “A Mediterranean Diet Enriched With Olive Oil is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular Risk”, The Journal of Clinical Endocrinology & Metaboli… [cited by applicant]
Hutchins-Wiese et al., “The Impact of Supplemental N-3 Long Chain Polyunsaturated Fatty Acids and Dietary Antioxidants on Physical Performance in Postmenopausal Women”, The Journal of Nutrition, Health and Aging, vol. 1… [cited by applicant]
Application for the Approval of Bonolive® (Standardised Olive Leaf Extract), Retrieved from <https://acnfp.food.gov.uk/sites/default/files/bonolive.nonconf.pdf>, Dec. 15, 2016, 77 Pages. [cited by applicant]
“Peach and Mango Flavour Ultra Concentrated Pre-Workout Formula”, Mintel, Record Id 5075085, 2017, 2 Pages. [cited by applicant]
Australian Office Action for Appl No. 2020273559 dated Jul. 21, 2025, 7 pages. [cited by applicant]
Bulotta et al., “Beneficial Effects of the Olive Oil Phenolic Components Oleuropein and Hydroxytyrosol: Focus on Protection against Cardiovascular and Metabolic Diseases”, Journal of Translational Medicine, vol. 12, 201… [cited by applicant]
Japanese Office Action for Appl No. 2021-565841 dated Aug. 12, 2025, 3 pages. [cited by applicant]