Granted Patent
B2
US 6,863,891 · App. 10/040,457 · Granted Mar 8, 2005
Oligopeptide lyophilisate, their preparation and use
Assignee:
Zentaris AG
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Abstract
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
Claims (2)
1. A method of treating female infertility which comprises administering, to a female undergoing controlled ovarian stimulation, an effective amount of pharmaceutical composition comprising a lyophilizate of a certrorelix solution containing 100-10,000 parts by weight of acetic acid per part of dissolved cetrorelix, thereby preventing premature ovulation.
2. The method according to claim 1 , wherein the lyophilizate further comprises a bulking agent.
Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 19, 2012
From: AETERNA ZENTARIS GMBH
To: ZENTARIS IVF GMBH
Reel/Frame 027886/0381 →
CHANGE OF NAME
Recorded Feb 2, 2012
From: ZENTARIS GMBH
To: AETERNA ZENTARIS GMBH
Reel/Frame 027646/0117 →
SECURITY AGREEMENT
Recorded Nov 22, 2011
From: COWEN HEALTHCARE ROYALTY PARTNERS, L.P. (SUCCESSOR OF CETRO INVESTORS, L.P.); VANDERBILT ROYALTY HOLDINGS L.P.; VANDERBILT ROYALTY SUB L.P.
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 027278/0184 →
SECURITY AGREEMENT
Recorded Nov 22, 2011
From: ZENTARIS IVF GMBH
To: CETRO INVESTORS, L.P.
Reel/Frame 027278/0053 →
CHANGE OF NAME
Recorded Oct 28, 2009
From: BLITZ F02-570 GMBH
To: ZENTARIS GMBH
Reel/Frame 023438/0004 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 24, 2002
From: ENGEL, JURGEN; WICHERT, BURKHARD; SAUERBIER, DIETER; REISSMANN, THOMAS
To: ZENTARIS AG
Reel/Frame 012932/0186 →
Priority Claims (1)
DE 43 05 225
· Feb 19, 1993
· national
Continuity (3)