Process for the preparation of a high purity composition comprising (7α, 17α)- 17-hydroxy- 7-methyl- 19-nor-17-pregn-5(10)-en-20-yn-3-one
View Patent ↗The invention pertains to a process for the preparation of a high purity composition of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one. The process provides for a composition with less than 0.5% of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-4-en-20-yn-3-one. This composition can be used as a source for the preparation of stable pharmaceutical dosage units.
1. A process for reducing the rate of formation of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-4-en-20-yn-3-one impurity in crystals of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one, wherein the (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one contains less than 0.5% by weight of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-4-en-20-yn-3-one as the impurity relative to (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one after drying, said process comprising:
aging crystals of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one in the presence of water for a period of time of at least 24 hours.
2. The process of claim 1 wherein the period of time lasts 3–6 days.
3. The process of claim 1 , wherein the crystals are formed in the last step of a synthesis comprising the steps of:
a. reacting (7α, 17α)-3,3-dimethoxy-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one in an organic solvent with a weak acidic aqueous solution,
b. pouring out the solution in water which is slightly alkaline, and
c. washing the crystals with water which is slightly alkaline.
4. The process of claim 1 , wherein the process comprises:
(i) washing crystals of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one with water,
(ii) aging crystals of (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one in the presence of water for a period of time of at least 24 hours, and
(iii) drying the (7α, 17α)-17-hydroxy-7-methyl-19-nor-17-pregn-5(10)-en-20-yn-3-one.
5. The process of claim 1 , wherein the water is alkaline.
6. The process of claim 5 , wherein the water is mixed with pyridine.
7. The process of claim 4 , wherein the crystals are obtained by filtration after crystallization.
8. The process of claim 4 , wherein the drying is carried out after at least 3 days.
9. The process of claim 1 , wherein the impurity is less than 0.25% by weight.
10. The process of claim 9 , wherein the impurity is less than 0.1% by weight.
11. The process of claim 4 , wherein the impurity is less than 0.25% by weight.
12. The process of claim 8 , wherein the impurity is less than 0.1% by weight.