Human CTLA-4 antibodies
The present invention provides human sequence antibodies against CTLA-4 and methods of treating human diseases, infections and other conditions using these antibodies.
1. An antibody comprising:
(a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:19; and
(b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:9,
wherein the antibody is capable of binding human CTLA-4.
2. An antibody comprising:
(a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:17; and
(b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:7,
wherein the antibody is capable of binding human CTLA4.
3. An antibody comprising:
(a) a heavy chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:23; and
(b) a light chain variable amino acid sequence having the amino acid sequence set forth in SEQ ID NO:13,
wherein the antibody is capable of binding human CTLA4.
4. An antibody capable of binding human CTLA4, which antibody comprises:
(a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:27, 32 and 37; and
(b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:24, 29 and 35.
5. An antibody capable of binding human CTLA4, which antibody comprises:
(a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:27, 33 and 37; and
(b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:25, 30 and 35.
6. An antibody capable of binding human CTLA4, which antibody comprises:
(a) a heavy chain variable region having CDR sequences set forth in SEQ ID NOS:28, 34 and 38; and
(b) a light chain variable region having CDR sequences set forth in SEQ ID NOS:26, 31 and 36.
7. An antibody capable of binding human CTLA4, which antibody comprises:
(a) a heavy chain variable region of a human V H 3-30.3 gene; and
(b) a light chain variable region of a human V K A-27 gene.
8. An antibody according to claim 7 , wherein the antibody is capable of binding human CTLA4 with a binding affinity of about 10 8 M −1 or greater.
9. An antibody according to claim 7 , wherein the antibody is capable of binding human CTLA4 with a binding affinity of about 10 9 M −1 or greater.
10. An antibody according to claim 7 , wherein the antibody inhibits binding of the human CTLA4 to B7-1 or to B7-2.
11. An antibody capable of binding human CTLA4, which antibody comprises:
(a) a heavy chain variable region of a human V H 3-33 gene; and
(b) a light chain variable region of a human V K L-15 gene.
12. An antibody according to claim 11 , wherein the antibody is capable of binding human CTLA4 with a binding affinity of about 10 8 M −1 or greater.
13. An antibody according to claim 11 , wherein the antibody is capable of binding human CTLA4 with a binding affinity of about 10 9 M[−1] −1 or greater.
14. An antibody according to claim 11 , wherein the antibody inhibits binding of the human CTLA4 to B7-1 or to B7-2.