Granted Patent
B2
US 7,034,121 · App. 09/772,103 · Granted Apr 25, 2006
Antibodies against CTLA4
Assignee:
Genetics Institue, LLC
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Abstract
The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.
Claims (2)
1. A humanized antibody that is specifically reactive with human CTLA4, wherein the antibody comprises the amino acid sequence shown in SEQ ID NO: 8.
2. A humanized antibody that is specifically reactive with human CTLA4, wherein the antibody comprises the amino acid sequence shown in SEQ ID NO: 10.
Assignments (5)
CHANGE OF NAME
Recorded Mar 1, 2006
From: GENETICS INSTITUTE, INC.
To: GENETICS INSTITUTE, LLC
Reel/Frame 017303/0157 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 10, 2006
From: PROTEIN DESIGN LABS, INC.
To: GENETICS INSTITUTE, INC.
Reel/Frame 017175/0625 →
CHANGE OF NAME
Recorded Mar 29, 2002
From: GENETICS INSTITUTE, INC.
To: GENETICS INSTITUTE, LLC
Reel/Frame 012772/0631 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 16, 2001
From: HINTON, PAUL R.; TSURUSHITA, NAOYA
To: PROTEIN DESIGN LABS, INC.
Reel/Frame 011990/0769 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 16, 2001
From: CARRENO, BEATRIZ M.; WOOD, CLIVE; TURNER, KATHERINE; COLLINS, MARY; GRAY, GARY S.; MORRIS, DONNA; O'HARA, DENISE
To: GENETICS INSTITUTE, INC.
Reel/Frame 011990/0844 →
Continuity (2)
Provisional Application
6017847300
· Jan 27, 2000