Container or bag mixing apparatuses and/or methods
A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.
1. A mixing system for use in mixing a fluid contained within a fluid container, the system comprising:
a support structure;
at least one movable squeezing element operably disposed relative to the support structure;
wherein the moveable squeezing element is a moveable clapping member;
a holding device adapted for holding the fluid container between the support structure and the movable squeezing element;
an irradiation source for irradiating the fluid contained within the fluid container; and
whereby the movable squeezing element is adapted to move so as to squeeze the fluid container against the support structure to thereby mix the fluid contained in the fluid container.
2. The mixing system according to claim 1 wherein the irradiation source irradiates the fluid while the fluid contained in the fluid container is thereby mixed.
3. A mixing system according to claim 1 in which the fluid to be mixed is whole blood.
4. A mixing system according to claim 1 in which the fluid to be mixed is a blood component.
5. A mixing system according to claim 1 in which the fluid to be mixed includes a pathogen reduction agent.
6. A mixing system according to claim 5 in which the pathogen reduction agent is a photosensitizer.
7. A mixing system according to claim 6 in which the photosensitizer is riboflavin.
8. A mixing system according to claim 6 in which the photosensitizer is a psoralen.
9. A mixing system according to claim 1 which further comprises a motor which is operably connected to the movable squeezing element to move the movable squeezing element.
10. A mixing system according to claim 9 in which the motor moves the movable squeezing element in a reciprocal motion, closed and open to alternately squeeze and release the fluid container.
11. A mixing system according to claim 1 in which the movable squeezing element is rotatable about a pivot point.
12. A mixing system according to claim 1 which further comprises a constriction element disposed in operative relationship with the fluid container.
13. A mixing system according to claim 12 in which the constriction element provides a narrowed fluid flow passage within the fluid container which thereby provides a vortex action of fluid being moved therein.
14. A mixing system according to claim 12 in which the constriction element is a clamp.
15. A mixing system according to claim 14 in which the clamp is removably connected to the support structure.
16. A mixing system according to claim 14 in which the clamp is permanently affixed to the support structure.
17. A mixing system according to claim 12 in which the constriction element is a feature of the container.
18. A mixing system according to claim 17 in which the feature of the container is a welded seam.
19. A mixing system according to claim 17 in which the feature of the container is a side indentation.
20. A mixing system according to claim 1 in which the fluid container is a flexible bag.
21. A mixing system according to claim 1 in which the fluid container is a substantially resilient container.
22. A mixing system according to claim 1 in which the irradiation source provides ligbt to at least two sides of the fluid container.
23. A mixing system according to claim 1 in which the fluid container is held in a substantially vertical orientation.
24. A mixing system according to claim 1 in which the fluid container is held in a substantially horizontal orientation.