Ocular solutions
Ocular solutions containing at least one macrolide antibiotic and/or mycophenolic acid provide anti-inflammatory, anti-cell proliferation, anti-cell migration, anti-angiogenesis, antimicrobial and antifungal effects. In one embodiment, the solution is administered intraocularly after cataract surgery before insertion of a replacement intraocular lens, resulting in reduced posterior capsular opacification which may eliminate the need for a subsequent surgery. The solution may be one that is invasively administered, for example, an irrigation or volume replacement solution containing at least one macrolide antibiotic such as tacrolimus, sirolimus, everolimus, cyclosporine, and ascomycin, or mycophenolic acid. The solution may be one that is non-invasively or topically administered in the form of drops, ointments, gels, creams, etc. and may include eye lubricants and contact lens solutions. The solution may contain a supratherapeutic concentration of agent(s) so that a therapeutic concentration of a topically administered solution accumulates in a diseased ocular structure sufficient to treat the disease.
1. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigimentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition comprising a concentration ranging between 0.5% w/w to about 10% w/w of a macrolide antibiotic and/or mycophenolic acid in a pharmaceutically acceptable topical formulation for a duration to achieve a concentration of the macrolide antibiotic and/or mycophenolic acid in a diseased posterior segment ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
2. The method of claim 1 wherein the macrolide antibiotic is selected from the group consisting of tacrolimus, Cyclosporin A, sirolimus, ascomycin, and everolimus.
3. The method of claim 1 wherein the macrolide antibiotic is selected from the group consisting of erythromycin, azithromycin, clarithromycin, lincomycin, dirithromycin, josamycin, spiramycin, diacetyl-midecamycin, tylosin, troleandomycin, roxithromycin, ABT-773, telithromycin, macrolides derived from leucomycins, and lincosamides.
4. The method of claim 1 wherein the composition is formulated as at least one selecting from the group consisting of a polymer, a microcapsule, a microsphere, a microvesicle, and a liposome.
5. The method of claim 1 for administration to at least one of an ocular mucosal surface or the conjunctiva.
6. The method of claim 1 wherein the concentration of the macrolide antibiotic and/or mycophenolic acid is from at least one of about 0.5% w/v to about 3% w/v , about 3% w/v to about 5% w/v , about 5% w/v , to about 10% w/v , or about 3% w/v to about 0.5% w/v .
7. The method of claim 1 for treating age related macular degeneration wherein the composition further comprises a cyclooxygenase inhibitor.
8. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigmentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition consisting essentially of tacrolimus at a concentration from 0.5% w/v to about 10% w/v in a pharmaceutically acceptable formulation for a duration to achieve a concentration in an internal ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
9. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigmentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition consisting essentially of Cyclosporin A at a concentration from 0.5% w/v to about 10% w/v in a pharmaceutically acceptable formulation for a duration to achieve a concentration in an internal ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
10. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigmentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition consisting essentially of sirolimus at a concentration from 0.5% w/v to about 10% w/v in a pharmaceutically acceptable formulation for a duration to achieve a concentration in an internal ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
11. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigmentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition consisting essentially of ascomycin at a concentration from 0.5% w/v to about 10% w/v in a pharmaceutically acceptable formulation for a duration to achieve a concentration in an internal ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
12. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule in a patient's eye comprising administering to the eye of a patient with retinopathy, retinitis pigmentosa, or age related macular degeneration a composition in an extended release formulation on a contact or intraocular lens, the composition consisting essentially of everolimus at a concentration from 0.5% w/v to about 10% w/v in a pharmaceutically acceptable formulation for a duration to achieve a concentration in an internal ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
13. A method to treat a posterior segment disease affecting at least one of a choroid, retina, uvea, or lens capsule of an eye in a patient having diabetic retinopathy, age related macular degeneration, or retinitis pigmentosa, the method comprising administering to the eye a composition comprising a concentration ranging between 0.1% w/w to about 10% w/w of a macrolide and/or mycophenolic acid in a pharmaceutically acceptable topical formulation for a duration to achieve a concentration of the macrolide antibiotic and/or mycophenolic in a diseased posterior segment ocular structure sufficient to treat the affected choroid, retina, uvea, or lens capsule.
14. The method of claim 13 wherein the composition further comprises at least one cyclooxygenase inhibitor.