Binding compounds for IL-27
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a polypeptide consisting of SEQ ID NO:2.
2. The antibody of claim 1 that is monoclonal.
3. The antibody of claim 1 that is a humanized or chimeric antibody.
4. The antibody or fragment of claim 1 , that is:
a) raised against a purified or recombinantly produced protein comprising SEQ ID NO:2;
b) Fab or F(ab)2;
c) a polyclonal antiserum;
d) detectably labeled;
e) sterile; or
f) in a buffered composition.
5. A kit comprising the antibody or fragment of claim 1 , and a compartment, wherein said antibody or fragment is contained within said compartment.
6. The kit of claim 5 wherein the antibody or fragment is detectably labeled.
7. The kit of claim 6 wherein the antibody or fragment is labeled with an enzyme, a fluorescent label, radioisotope or biotinylation.
8. An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a polypeptide consisting of SEQ ID NO:6.
9. The antibody of claim 8 that is monoclonal.
10. The antibody of claim 8 that is a humanized or chimeric antibody.
11. The antibody or fragment of claim 8 , that is:
a) raised against a purified or recombinantly produced protein comprising SEQ ID NO:6;
b) Fab or F(ab)2;
c) a polyclonal antiserum;
d) detectably labeled;
e) sterile; or
f) in a buffered composition.
12. A kit comprising the antibody or fragment of claim 8 , and a compartment, wherein said antibody or fragment is contained within said compartment.
13. The kit of claim 12 wherein the antibody or fragment is detectably labeled.
14. The kit of claim 13 wherein the antibody or fragment is labeled with an enzyme, a fluorescent label, radioisotope or biotinylation.