Method of treating bacterial infections using gemifloxacin or a salt thereof and a β-lactam antibiotic
The present invention relates to a method of treating anti-bacterial infections which method comprises the separate, simultaneous or sequential administration to a patient in need thereof, of an effective amount of gemifloxacin or a salt thereof and a β-lactam antibiotic.
1. A method of treating bacterial infections caused by at least one of Pseudomonas aeruginosa, E. faecalis and E. coli , which method comprises
simultaneous or sequential administration to a patient in need thereof, of a synergistic amount of gemifloxacin or a salt thereof and at least one cephalo-sporin selected from the group consisting of cefotaxime, ceflacor and ceftazidime.
2. The method according to claim 1 , wherein said gemifloxacin is gemifloxacin mesylate.
3. The method according to claim 1 , wherein the cephalo-sporin is cefotaxime.
4. The method according to claim 1 , wherein the cephalo-sporin is ceftazidime.
5. The method according to claim 1 , wherein gemifloxacin or a salt thereof and cephalo-sporin are administered in a ratio of from about 10:1 to about 1:10 (W/W).
6. The method according to claim 1 , in which of gemifloxacin or a salt thereof and cephalo-sporin are administered simultaneously.
7. The method according to claim 6 , achieved by the co-administration of separate compositions comprising gemifloxacin or a salt thereof and a cephalo-sporin.
8. The method according to any one of claims 1 , 2 , 3 , 4 or 6, wherein the bacterial infection is caused by Pseudomonas aeruginosa.