Liposomal antineoplastic drugs and uses thereof
This invention relates to liposomal antineoplastic agents (e.g., camptothecin) compositions and methods of using such compositions for treating neoplasia and for inhibiting angiogenesis. The compositions and methods are useful for modulating the plasma circulation half-life of an active agent.
1. A liposomal formulation, said liposomal formulation comprising a liposome having vinorelbine in solution and precipitated vinorelbine, wherein the precipitated vinorelbine in said liposome is at least 50% of the total vinorelbine, wherein said liposome comprises sphingomyelin and cholesterol at a ratio in the range of about 75/25 mol %/mol % sphingomyelinl/cholesterol to about 30/50 mol %/mol % sphingomyelinl/cholesterol, and wherein the ratio of said vinorelbine to lipid is 0.2-0.3:1 (w/w).
2. The liposomal formulation of claim 1 , wherein said liposome comprises sphingomyelin and cholesterol in a 55:45 molar ratio.
3. The liposomal formulation of claim 1 , wherein said liposome comprises sphingomyelin and cholesterol in a 50:50 molar ratio.
4. The liposomal formulation of claim 1 , wherein the ratio of said vinorelbine to said lipid is about 0.3:1 (w/w).
5. A liposomal formulation, said liposomal formulation comprising a liposome having vinorelbine in solution and precipitated vinorelbine, wherein the precipitated vinorelbine in said liposome is at least 50% of the total vinorelbine, wherein said liposome comprises sphingomyelin and cholesterol at a ratio of about 55/45 mol %/mol % sphingomyelin/cholesterol, and wherein the ratio of said vinorelbine to lipid is about 0.3:1 (w/w).