Animal model, cells, and treatment for malignant melanoma
The present invention provides transgenic non-human animal models and cell lines which express a metabotropic glutamate receptor 1 in a melanocyte-specific manner and, as a result, exhibit a predisposition to the development of melanoma. The invention further teaches methods of using the transgenic animals and cell lines to identify therapeutic agents. Diagnostic methods for detecting a melanoma are also provided.
1. A transgenic mouse whose genome comprises a transgene including the coding sequence of SEQ ID NO:1 encoding a metabotropic glutamate receptor 1 operably linked to the melanocyte-specific promoter of SEQ ID NO:14, wherein said transgenic mouse expresses the metabotropic glutamate receptor 1 in melanocytes, develops lesions on hairless skin, and lacks pigmentation.